Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials

We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of b...

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Detalles Bibliográficos
Autores principales: Khatoon, Zohra, Guzmán-Soto, Irene, McTiernan, Christopher D., Lazurko, Caitlin, Simpson, Fiona, Zhang, Li, Cortes, David, Mah, Thien-Fah, Griffith, May, Alarcon, Emilio I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054791/
https://www.ncbi.nlm.nih.gov/pubmed/35517329
http://dx.doi.org/10.1039/d0ra03659e
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author Khatoon, Zohra
Guzmán-Soto, Irene
McTiernan, Christopher D.
Lazurko, Caitlin
Simpson, Fiona
Zhang, Li
Cortes, David
Mah, Thien-Fah
Griffith, May
Alarcon, Emilio I.
author_facet Khatoon, Zohra
Guzmán-Soto, Irene
McTiernan, Christopher D.
Lazurko, Caitlin
Simpson, Fiona
Zhang, Li
Cortes, David
Mah, Thien-Fah
Griffith, May
Alarcon, Emilio I.
author_sort Khatoon, Zohra
collection PubMed
description We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our in situ grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets.
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spelling pubmed-90547912022-05-04 Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials Khatoon, Zohra Guzmán-Soto, Irene McTiernan, Christopher D. Lazurko, Caitlin Simpson, Fiona Zhang, Li Cortes, David Mah, Thien-Fah Griffith, May Alarcon, Emilio I. RSC Adv Chemistry We report the development and use of a light-mediated in situ grafting technology for the surface modification of biosynthetic corneal implants with peptide-capped nanoparticles (15–65 nm). The resulting materials have antimicrobial properties in bacterial suspension and also reduced the extent of biofilm formation. Our in situ grafting technology offers a rapid route for the introduction of antimicrobial properties to premoulded corneal implants, and potentially other soft implant targets. The Royal Society of Chemistry 2020-06-22 /pmc/articles/PMC9054791/ /pubmed/35517329 http://dx.doi.org/10.1039/d0ra03659e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Khatoon, Zohra
Guzmán-Soto, Irene
McTiernan, Christopher D.
Lazurko, Caitlin
Simpson, Fiona
Zhang, Li
Cortes, David
Mah, Thien-Fah
Griffith, May
Alarcon, Emilio I.
Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title_full Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title_fullStr Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title_full_unstemmed Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title_short Nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
title_sort nanoengineering the surface of corneal implants: towards functional anti-microbial and biofilm materials
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054791/
https://www.ncbi.nlm.nih.gov/pubmed/35517329
http://dx.doi.org/10.1039/d0ra03659e
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