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Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study

Patients with neuromuscular disease often suffer from weak and ineffective cough resulting in mucus retention and increased risk for chest infections. Different airway clearance techniques have been proposed, one of them being the insufflator/exsufflator technique. So far, the immediate physiologica...

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Autores principales: Casaulta, Carmen, Messerli, Florence, Rodriguez, Romy, Klein, Andrea, Riedel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054802/
https://www.ncbi.nlm.nih.gov/pubmed/35488044
http://dx.doi.org/10.1038/s41598-022-11190-z
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author Casaulta, Carmen
Messerli, Florence
Rodriguez, Romy
Klein, Andrea
Riedel, Thomas
author_facet Casaulta, Carmen
Messerli, Florence
Rodriguez, Romy
Klein, Andrea
Riedel, Thomas
author_sort Casaulta, Carmen
collection PubMed
description Patients with neuromuscular disease often suffer from weak and ineffective cough resulting in mucus retention and increased risk for chest infections. Different airway clearance techniques have been proposed, one of them being the insufflator/exsufflator technique. So far, the immediate physiological effects of the insufflator/exsufflator technique on ventilation distribution and lung volumes are not known. We aimed to describe the immediate effects of the insufflator/exsufflator technique on different lung volumes, forced flows and ventilation distribution. Eight subjects (age 5.8–15.2 years) performed lung function tests including spirometry, multiple breath washout and electrical impedance tomography before and after a regular a chest physiotherapy session with an insufflator/exsufflator device. Forced lung volumes and flows as well as parameters of ventilation distribution derived from multiple breath washout and electrical impedance tomography were compared to assess the short-term effect of the therapy. In this small group of stable paediatric subjects with neuromuscular disease we could not demonstrate any short-term effects of insufflation/exsufflation manoeuvres on lung volumes, expiratory flows and ventilation distribution. With the currently used protocol of the insufflation/exsufflation manoeuvre, we cannot demonstrate any immediate changes in lung function.
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spelling pubmed-90548022022-05-01 Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study Casaulta, Carmen Messerli, Florence Rodriguez, Romy Klein, Andrea Riedel, Thomas Sci Rep Article Patients with neuromuscular disease often suffer from weak and ineffective cough resulting in mucus retention and increased risk for chest infections. Different airway clearance techniques have been proposed, one of them being the insufflator/exsufflator technique. So far, the immediate physiological effects of the insufflator/exsufflator technique on ventilation distribution and lung volumes are not known. We aimed to describe the immediate effects of the insufflator/exsufflator technique on different lung volumes, forced flows and ventilation distribution. Eight subjects (age 5.8–15.2 years) performed lung function tests including spirometry, multiple breath washout and electrical impedance tomography before and after a regular a chest physiotherapy session with an insufflator/exsufflator device. Forced lung volumes and flows as well as parameters of ventilation distribution derived from multiple breath washout and electrical impedance tomography were compared to assess the short-term effect of the therapy. In this small group of stable paediatric subjects with neuromuscular disease we could not demonstrate any short-term effects of insufflation/exsufflation manoeuvres on lung volumes, expiratory flows and ventilation distribution. With the currently used protocol of the insufflation/exsufflation manoeuvre, we cannot demonstrate any immediate changes in lung function. Nature Publishing Group UK 2022-04-29 /pmc/articles/PMC9054802/ /pubmed/35488044 http://dx.doi.org/10.1038/s41598-022-11190-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Casaulta, Carmen
Messerli, Florence
Rodriguez, Romy
Klein, Andrea
Riedel, Thomas
Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title_full Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title_fullStr Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title_full_unstemmed Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title_short Changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
title_sort changes in ventilation distribution in children with neuromuscular disease using the insufflator/exsufflator technique: an observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054802/
https://www.ncbi.nlm.nih.gov/pubmed/35488044
http://dx.doi.org/10.1038/s41598-022-11190-z
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