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Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification
Porous liquids with chemical separation properties are quite well-studied in general, but there is only a handful of reports in the context of identification and separation of non-gaseous molecules. Herein, we report a Type II porous ionic liquid composed of coordination cages that exhibits exceptio...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054828/ https://www.ncbi.nlm.nih.gov/pubmed/35487897 http://dx.doi.org/10.1038/s41467-022-30092-2 |
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author | Zhang, Zhuxiu Yang, Baolin Zhang, Bingjie Cui, Mifen Tang, Jihai Qiao, Xu |
author_facet | Zhang, Zhuxiu Yang, Baolin Zhang, Bingjie Cui, Mifen Tang, Jihai Qiao, Xu |
author_sort | Zhang, Zhuxiu |
collection | PubMed |
description | Porous liquids with chemical separation properties are quite well-studied in general, but there is only a handful of reports in the context of identification and separation of non-gaseous molecules. Herein, we report a Type II porous ionic liquid composed of coordination cages that exhibits exceptional selectivity towards l-tryptophan (l-Trp) over other aromatic amino acids. A previously known class of anionic organic–inorganic hybrid doughnut-like cage (HD) is dissolved in trihexyltetradecylphosphonium chloride (THTP_Cl). The resulting liquid, HD/THTP_Cl, is thereby composed of common components, facile to prepare, and exhibit room temperature fluidity. The permanent porosity is manifested by the high-pressure isotherm for CH(4) and modeling studies. With evidence from time-dependent amino acid uptake, competitive extraction studies and molecular dynamic simulations, HD/THTP_Cl exhibit better selectivity towards l-Trp than other solid state sorbents, and we attribute it to not only the intrinsic porosity of HD but also the host-guest interactions between HD and l-Trp. Specifically, each HD unit is filled with nearly 5 l-Trp molecules, which is higher than the l-Trp occupation in the structure unit of other benchmark metal-organic frameworks. |
format | Online Article Text |
id | pubmed-9054828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90548282022-05-01 Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification Zhang, Zhuxiu Yang, Baolin Zhang, Bingjie Cui, Mifen Tang, Jihai Qiao, Xu Nat Commun Article Porous liquids with chemical separation properties are quite well-studied in general, but there is only a handful of reports in the context of identification and separation of non-gaseous molecules. Herein, we report a Type II porous ionic liquid composed of coordination cages that exhibits exceptional selectivity towards l-tryptophan (l-Trp) over other aromatic amino acids. A previously known class of anionic organic–inorganic hybrid doughnut-like cage (HD) is dissolved in trihexyltetradecylphosphonium chloride (THTP_Cl). The resulting liquid, HD/THTP_Cl, is thereby composed of common components, facile to prepare, and exhibit room temperature fluidity. The permanent porosity is manifested by the high-pressure isotherm for CH(4) and modeling studies. With evidence from time-dependent amino acid uptake, competitive extraction studies and molecular dynamic simulations, HD/THTP_Cl exhibit better selectivity towards l-Trp than other solid state sorbents, and we attribute it to not only the intrinsic porosity of HD but also the host-guest interactions between HD and l-Trp. Specifically, each HD unit is filled with nearly 5 l-Trp molecules, which is higher than the l-Trp occupation in the structure unit of other benchmark metal-organic frameworks. Nature Publishing Group UK 2022-04-29 /pmc/articles/PMC9054828/ /pubmed/35487897 http://dx.doi.org/10.1038/s41467-022-30092-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhang, Zhuxiu Yang, Baolin Zhang, Bingjie Cui, Mifen Tang, Jihai Qiao, Xu Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title | Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title_full | Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title_fullStr | Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title_full_unstemmed | Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title_short | Type II porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
title_sort | type ii porous ionic liquid based on metal-organic cages that enables l-tryptophan identification |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054828/ https://www.ncbi.nlm.nih.gov/pubmed/35487897 http://dx.doi.org/10.1038/s41467-022-30092-2 |
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