RNF43 R117fs mutant positively regulates Wnt/β-catenin signaling by failing to internalize FZD expressed on the cell surface

RING finger protein 43 (RNF43) encodes the transmembrane E3 ubiquitin ligase, which targets the Wnt receptor Frizzled (FZD). RNF43 mutations have been discovered in various human cancers including colon, pancreatic, stomach, ovarian, and liver cancers. Functional studies on RNF43 missense mutations...

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Detalles Bibliográficos
Autores principales: Cho, A-Ri, Sul, Hee Jung, Kim, Yoo Jin, Kim, Bohyun, Zang, Dae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054848/
https://www.ncbi.nlm.nih.gov/pubmed/35487932
http://dx.doi.org/10.1038/s41598-022-10868-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054848/
https://www.ncbi.nlm.nih.gov/pubmed/35487932
http://dx.doi.org/10.1038/s41598-022-10868-8

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