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Pharmacokinetics of metronomic temozolomide in cerebrospinal fluid of children with malignant central nervous system tumors

PURPOSE: Although temozolomide is widely used in the treatment of childhood central nervous system (CNS) tumors, information on its pharmacokinetic profile in the brain or cerebrospinal fluid (CSF) is sparse. This study aimed at investigating whether measurable and clinically relevant concentrations...

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Detalles Bibliográficos
Autores principales:	Büsker, Sören, Jäger, Walter, Poschner, Stefan, Mayr, Lisa, Al Jalali, Valentin, Gojo, Johannes, Azizi, Amedeo A., Ullah, Sami, Bilal, Muhammad, El Tabei, Lobna, Fuhr, Uwe, Peyrl, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054874/ https://www.ncbi.nlm.nih.gov/pubmed/35355137 http://dx.doi.org/10.1007/s00280-022-04424-4

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