Mitofusin 1 and 2 regulation of mitochondrial DNA content is a critical determinant of glucose homeostasis

The dynamin-like GTPases Mitofusin 1 and 2 (Mfn1 and Mfn2) are essential for mitochondrial function, which has been principally attributed to their regulation of fission/fusion dynamics. Here, we report that Mfn1 and 2 are critical for glucose-stimulated insulin secretion (GSIS) primarily through co...

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Detalles Bibliográficos
Autores principales: Sidarala, Vaibhav, Zhu, Jie, Levi-D’Ancona, Elena, Pearson, Gemma L., Reck, Emma C., Walker, Emily M., Kaufman, Brett A., Soleimanpour, Scott A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055072/
https://www.ncbi.nlm.nih.gov/pubmed/35487893
http://dx.doi.org/10.1038/s41467-022-29945-7

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