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Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055185/ https://www.ncbi.nlm.nih.gov/pubmed/35517446 http://dx.doi.org/10.1039/d0ra05106c |
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author | Abdel-Raoof, Ahmed M. Osman, Ayman O. E. El-Desouky, Ebrahim A. Abdel-Fattah, Ashraf Abdul-Kareem, Rady F. Elgazzar, Elsayed |
author_facet | Abdel-Raoof, Ahmed M. Osman, Ayman O. E. El-Desouky, Ebrahim A. Abdel-Fattah, Ashraf Abdul-Kareem, Rady F. Elgazzar, Elsayed |
author_sort | Abdel-Raoof, Ahmed M. |
collection | PubMed |
description | A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn(2)O(3) nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn(2)O(3):Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10(−6) to 1 × 10(−2) mol L(−1) at 25 ± °C with a detection limit of 2.84 × 10(−7) mol L(−1). It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms. |
format | Online Article Text |
id | pubmed-9055185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90551852022-05-04 Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology Abdel-Raoof, Ahmed M. Osman, Ayman O. E. El-Desouky, Ebrahim A. Abdel-Fattah, Ashraf Abdul-Kareem, Rady F. Elgazzar, Elsayed RSC Adv Chemistry A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn(2)O(3) nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn(2)O(3):Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10(−6) to 1 × 10(−2) mol L(−1) at 25 ± °C with a detection limit of 2.84 × 10(−7) mol L(−1). It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms. The Royal Society of Chemistry 2020-07-01 /pmc/articles/PMC9055185/ /pubmed/35517446 http://dx.doi.org/10.1039/d0ra05106c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Abdel-Raoof, Ahmed M. Osman, Ayman O. E. El-Desouky, Ebrahim A. Abdel-Fattah, Ashraf Abdul-Kareem, Rady F. Elgazzar, Elsayed Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title | Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title_full | Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title_fullStr | Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title_full_unstemmed | Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title_short | Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
title_sort | fabrication of an (α-mn(2)o(3):co)-decorated cnt highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055185/ https://www.ncbi.nlm.nih.gov/pubmed/35517446 http://dx.doi.org/10.1039/d0ra05106c |
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