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Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology

A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductor...

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Autores principales: Abdel-Raoof, Ahmed M., Osman, Ayman O. E., El-Desouky, Ebrahim A., Abdel-Fattah, Ashraf, Abdul-Kareem, Rady F., Elgazzar, Elsayed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055185/
https://www.ncbi.nlm.nih.gov/pubmed/35517446
http://dx.doi.org/10.1039/d0ra05106c
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author Abdel-Raoof, Ahmed M.
Osman, Ayman O. E.
El-Desouky, Ebrahim A.
Abdel-Fattah, Ashraf
Abdul-Kareem, Rady F.
Elgazzar, Elsayed
author_facet Abdel-Raoof, Ahmed M.
Osman, Ayman O. E.
El-Desouky, Ebrahim A.
Abdel-Fattah, Ashraf
Abdul-Kareem, Rady F.
Elgazzar, Elsayed
author_sort Abdel-Raoof, Ahmed M.
collection PubMed
description A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn(2)O(3) nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn(2)O(3):Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10(−6) to 1 × 10(−2) mol L(−1) at 25 ± °C with a detection limit of 2.84 × 10(−7) mol L(−1). It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms.
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spelling pubmed-90551852022-05-04 Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology Abdel-Raoof, Ahmed M. Osman, Ayman O. E. El-Desouky, Ebrahim A. Abdel-Fattah, Ashraf Abdul-Kareem, Rady F. Elgazzar, Elsayed RSC Adv Chemistry A new chemically optimized screen-printed electrode modified with a cobalt-doped α-Mn(2)O(3) nanostructure on carbon nanotube paste (α-Mn(2)O(3):Co@CNTs) has been constructed for the recognition of cyclobenzaprine hydrochloride. The prepared paste is based on the incorporation of oxide ion conductors, such as the α-Mn(2)O(3) nanostructure with cobalt and ion pairs (tetraphenyl borate coupled with the drug), as electroactive species in the screen-printed electrode to increase the sensor surface area and decrease electrical resistance. The central composite design is a useful methodology for the estimation and modeling of the exact optimum parameters specifically designed for this process. This is a good way to graphically clarify the relationship between various experimental variables and the slope response. The proposed sensor, α-Mn(2)O(3):Co@CNTs, possesses very good sensitivity and the ability to recognize the drug over the concentration range of 1 × 10(−6) to 1 × 10(−2) mol L(−1) at 25 ± °C with a detection limit of 2.84 × 10(−7) mol L(−1). It exhibits a reproducible potential and stable linear response for six months at a Nernstian slope of 58.96 ± 0.76 mV per decade. The proposed electrode approach has been successfully applied in the direct determination of the drug in its pure and dosage forms. The Royal Society of Chemistry 2020-07-01 /pmc/articles/PMC9055185/ /pubmed/35517446 http://dx.doi.org/10.1039/d0ra05106c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Abdel-Raoof, Ahmed M.
Osman, Ayman O. E.
El-Desouky, Ebrahim A.
Abdel-Fattah, Ashraf
Abdul-Kareem, Rady F.
Elgazzar, Elsayed
Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title_full Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title_fullStr Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title_full_unstemmed Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title_short Fabrication of an (α-Mn(2)O(3):Co)-decorated CNT highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
title_sort fabrication of an (α-mn(2)o(3):co)-decorated cnt highly sensitive screen printed electrode for the optimization and electrochemical determination of cyclobenzaprine hydrochloride using response surface methodology
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055185/
https://www.ncbi.nlm.nih.gov/pubmed/35517446
http://dx.doi.org/10.1039/d0ra05106c
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