Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment

In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced. Acrylic acid was polymerized via the Reversible Addition Fragmentation Chain Transfer method (RAFT) in the presence of an initiator and the obtained polyacrylic acid was copolymerized with aniline...

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Detalles Bibliográficos
Autores principales: Bagheri, Nazanin, Mansour Lakouraj, Moslem, Nabavi, Seyed Reza, Tashakkorian, Hamed, Mohseni, Mojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055239/
https://www.ncbi.nlm.nih.gov/pubmed/35517464
http://dx.doi.org/10.1039/d0ra03779f
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author Bagheri, Nazanin
Mansour Lakouraj, Moslem
Nabavi, Seyed Reza
Tashakkorian, Hamed
Mohseni, Mojtaba
author_facet Bagheri, Nazanin
Mansour Lakouraj, Moslem
Nabavi, Seyed Reza
Tashakkorian, Hamed
Mohseni, Mojtaba
author_sort Bagheri, Nazanin
collection PubMed
description In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced. Acrylic acid was polymerized via the Reversible Addition Fragmentation Chain Transfer method (RAFT) in the presence of an initiator and the obtained polyacrylic acid was copolymerized with aniline at room temperature. As the main achievements of this work, the resulting block copolymer with nanosized structure revealed favorable solubility in polar solvents, as well as excellent antibacterial and anticancer activities. Therefore, it is an appropriate candidate for medical applications such as wound healing and cancer therapy, especially in HT29 treatment.
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spelling pubmed-90552392022-05-04 Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment Bagheri, Nazanin Mansour Lakouraj, Moslem Nabavi, Seyed Reza Tashakkorian, Hamed Mohseni, Mojtaba RSC Adv Chemistry In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced. Acrylic acid was polymerized via the Reversible Addition Fragmentation Chain Transfer method (RAFT) in the presence of an initiator and the obtained polyacrylic acid was copolymerized with aniline at room temperature. As the main achievements of this work, the resulting block copolymer with nanosized structure revealed favorable solubility in polar solvents, as well as excellent antibacterial and anticancer activities. Therefore, it is an appropriate candidate for medical applications such as wound healing and cancer therapy, especially in HT29 treatment. The Royal Society of Chemistry 2020-07-02 /pmc/articles/PMC9055239/ /pubmed/35517464 http://dx.doi.org/10.1039/d0ra03779f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Bagheri, Nazanin
Mansour Lakouraj, Moslem
Nabavi, Seyed Reza
Tashakkorian, Hamed
Mohseni, Mojtaba
Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title_full Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title_fullStr Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title_full_unstemmed Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title_short Synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment
title_sort synthesis of bioactive polyaniline-b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for ht29 treatment
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055239/
https://www.ncbi.nlm.nih.gov/pubmed/35517464
http://dx.doi.org/10.1039/d0ra03779f
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