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The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture

The aim of this study is to determine whether the use of tranexamic acid (TXA) in patients with hip fracture reduces intraoperative and postoperative blood loss, and on the other hand, whether it increases thromboembolic risk. The study was performed on patients with hip fracture for a period of one...

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Autores principales: Stojadinovic, Ivan B., Ristic, Branko M., Knezevic, Dragan R., Milenkovic, Zoran S., Prodanovic, Nikola S., Zornic, Nenad R., Milosevic, Jelena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055253/
https://www.ncbi.nlm.nih.gov/pubmed/35582194
http://dx.doi.org/10.1515/med-2022-0482
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author Stojadinovic, Ivan B.
Ristic, Branko M.
Knezevic, Dragan R.
Milenkovic, Zoran S.
Prodanovic, Nikola S.
Zornic, Nenad R.
Milosevic, Jelena B.
author_facet Stojadinovic, Ivan B.
Ristic, Branko M.
Knezevic, Dragan R.
Milenkovic, Zoran S.
Prodanovic, Nikola S.
Zornic, Nenad R.
Milosevic, Jelena B.
author_sort Stojadinovic, Ivan B.
collection PubMed
description The aim of this study is to determine whether the use of tranexamic acid (TXA) in patients with hip fracture reduces intraoperative and postoperative blood loss, and on the other hand, whether it increases thromboembolic risk. The study was performed on patients with hip fracture for a period of one year. Patients were divided into two groups (1:1): the first group receiving TXA and the second group receiving placebo. The amount of blood aspiration during the surgery was measured as well as drainage in the postoperative period of 24 h. The occurrence of deep vein thrombosis (DVT) was monitored before and after the surgery by ultrasound of the lower extremities. The amount of total blood loss was two times lower in patients who received TXA (291.8 ± 65.5 mL of blood vs 634.7 ± 150.5 mL of blood). Among the patients who developed DVT, one patient was from the group that did not receive TXA, and two patients were from the group that received TXA. The use of TXA in patients with hip fracture significantly reduces intraoperative and postoperative blood loss, without a significant thromboembolic risk.
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spelling pubmed-90552532022-05-16 The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture Stojadinovic, Ivan B. Ristic, Branko M. Knezevic, Dragan R. Milenkovic, Zoran S. Prodanovic, Nikola S. Zornic, Nenad R. Milosevic, Jelena B. Open Med (Wars) Research Article The aim of this study is to determine whether the use of tranexamic acid (TXA) in patients with hip fracture reduces intraoperative and postoperative blood loss, and on the other hand, whether it increases thromboembolic risk. The study was performed on patients with hip fracture for a period of one year. Patients were divided into two groups (1:1): the first group receiving TXA and the second group receiving placebo. The amount of blood aspiration during the surgery was measured as well as drainage in the postoperative period of 24 h. The occurrence of deep vein thrombosis (DVT) was monitored before and after the surgery by ultrasound of the lower extremities. The amount of total blood loss was two times lower in patients who received TXA (291.8 ± 65.5 mL of blood vs 634.7 ± 150.5 mL of blood). Among the patients who developed DVT, one patient was from the group that did not receive TXA, and two patients were from the group that received TXA. The use of TXA in patients with hip fracture significantly reduces intraoperative and postoperative blood loss, without a significant thromboembolic risk. De Gruyter 2022-04-29 /pmc/articles/PMC9055253/ /pubmed/35582194 http://dx.doi.org/10.1515/med-2022-0482 Text en © 2022 Ivan B. Stojadinovic et al., published by De Gruyter https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Stojadinovic, Ivan B.
Ristic, Branko M.
Knezevic, Dragan R.
Milenkovic, Zoran S.
Prodanovic, Nikola S.
Zornic, Nenad R.
Milosevic, Jelena B.
The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title_full The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title_fullStr The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title_full_unstemmed The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title_short The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
title_sort effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055253/
https://www.ncbi.nlm.nih.gov/pubmed/35582194
http://dx.doi.org/10.1515/med-2022-0482
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