Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. Th...

Descripción completa

Detalles Bibliográficos
Autores principales: Águila-Rosas, Javier, Quirino-Barreda, Tomás, Leyva-Gómez, Gerardo, González-Zamora, Eduardo, Ibarra, Ilich A., Lima, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055305/
https://www.ncbi.nlm.nih.gov/pubmed/35518595
http://dx.doi.org/10.1039/d0ra03636f
Descripción
Sumario:Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine–MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.

Ejemplares similares