Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system

Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. Th...

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Autores principales: Águila-Rosas, Javier, Quirino-Barreda, Tomás, Leyva-Gómez, Gerardo, González-Zamora, Eduardo, Ibarra, Ilich A., Lima, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055305/
https://www.ncbi.nlm.nih.gov/pubmed/35518595
http://dx.doi.org/10.1039/d0ra03636f
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author Águila-Rosas, Javier
Quirino-Barreda, Tomás
Leyva-Gómez, Gerardo
González-Zamora, Eduardo
Ibarra, Ilich A.
Lima, Enrique
author_facet Águila-Rosas, Javier
Quirino-Barreda, Tomás
Leyva-Gómez, Gerardo
González-Zamora, Eduardo
Ibarra, Ilich A.
Lima, Enrique
author_sort Águila-Rosas, Javier
collection PubMed
description Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine–MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells.
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spelling pubmed-90553052022-05-04 Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system Águila-Rosas, Javier Quirino-Barreda, Tomás Leyva-Gómez, Gerardo González-Zamora, Eduardo Ibarra, Ilich A. Lima, Enrique RSC Adv Chemistry Sulfadiazine (SDZ), a bacteriostatic agent, was hosted in a metal–organic framework, specifically in MIL-53(Al) and modified-zinc MIL-53(Al,Zn). Materials were characterized structural, and texturally. Both hosts loaded sulfadiazine but they were differenced regarding the release of sulfadiazine. The presence of zinc plays a significant role to the modulation of sulfadiazine–MOF interactions. Release of sulfadiazine from sulfadiazine@MOFs was monitored in vitro and ex vivo conditions. A kinetic release model is proposed for in vitro sulfadiazine release. Remarkably, the materials did not show cytotoxicity against eukaryote cells. The Royal Society of Chemistry 2020-07-07 /pmc/articles/PMC9055305/ /pubmed/35518595 http://dx.doi.org/10.1039/d0ra03636f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Águila-Rosas, Javier
Quirino-Barreda, Tomás
Leyva-Gómez, Gerardo
González-Zamora, Eduardo
Ibarra, Ilich A.
Lima, Enrique
Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title_full Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title_fullStr Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title_full_unstemmed Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title_short Sulfadiazine hosted in MIL-53(Al) as a biocide topical delivery system
title_sort sulfadiazine hosted in mil-53(al) as a biocide topical delivery system
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055305/
https://www.ncbi.nlm.nih.gov/pubmed/35518595
http://dx.doi.org/10.1039/d0ra03636f
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