Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as...

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Detalles Bibliográficos
Autores principales: Miao, Weihang, Ye, Pingting, Bai, Mengjiao, Yang, Zhixin, Duan, Suyue, Duan, Hengpan, Wang, Xuequan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055358/
https://www.ncbi.nlm.nih.gov/pubmed/35517437
http://dx.doi.org/10.1039/d0ra05217e
Descripción
Sumario:An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates.

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