Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as...

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Autores principales: Miao, Weihang, Ye, Pingting, Bai, Mengjiao, Yang, Zhixin, Duan, Suyue, Duan, Hengpan, Wang, Xuequan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055358/
https://www.ncbi.nlm.nih.gov/pubmed/35517437
http://dx.doi.org/10.1039/d0ra05217e
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author Miao, Weihang
Ye, Pingting
Bai, Mengjiao
Yang, Zhixin
Duan, Suyue
Duan, Hengpan
Wang, Xuequan
author_facet Miao, Weihang
Ye, Pingting
Bai, Mengjiao
Yang, Zhixin
Duan, Suyue
Duan, Hengpan
Wang, Xuequan
author_sort Miao, Weihang
collection PubMed
description An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates.
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spelling pubmed-90553582022-05-04 Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions Miao, Weihang Ye, Pingting Bai, Mengjiao Yang, Zhixin Duan, Suyue Duan, Hengpan Wang, Xuequan RSC Adv Chemistry An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates. The Royal Society of Chemistry 2020-07-02 /pmc/articles/PMC9055358/ /pubmed/35517437 http://dx.doi.org/10.1039/d0ra05217e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Miao, Weihang
Ye, Pingting
Bai, Mengjiao
Yang, Zhixin
Duan, Suyue
Duan, Hengpan
Wang, Xuequan
Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title_full Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title_fullStr Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title_full_unstemmed Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title_short Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
title_sort iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055358/
https://www.ncbi.nlm.nih.gov/pubmed/35517437
http://dx.doi.org/10.1039/d0ra05217e
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