Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine

An effective synthetic method to achieve difluoromethylated oxazolidin-2-imine has been developed via visible-light promoted three-component tandem reaction of aryl allylamines, 2-BTSO2CF2H (BT = Benzothiazole) and isocyanates. This method features mild reaction conditions and good functional group...

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Detalles Bibliográficos
Autores principales: Bao, Kun, Wei, Jun, Yan, Huihui, Sheng, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055360/
https://www.ncbi.nlm.nih.gov/pubmed/35518621
http://dx.doi.org/10.1039/d0ra04729e
Descripción
Sumario:An effective synthetic method to achieve difluoromethylated oxazolidin-2-imine has been developed via visible-light promoted three-component tandem reaction of aryl allylamines, 2-BTSO2CF2H (BT = Benzothiazole) and isocyanates. This method features mild reaction conditions and good functional group tolerance, and the reaction mechanism was confirmed by experiments and interpreted by quantum chemical calculations.

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