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The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
Porous β-tricalcium phosphate (β-Ca(3)(PO(4))(2), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055648/ https://www.ncbi.nlm.nih.gov/pubmed/35519120 http://dx.doi.org/10.1039/d0ra02388d |
Sumario: | Porous β-tricalcium phosphate (β-Ca(3)(PO(4))(2), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method. In the synthesis process, G-β-TCP was prepared via an in situ synthesis method, and then silver nanoparticles and HAp particles were coated on the surface of the G-β-TCP scaffold in an orderly fashion using dopamine as a binder. From the results of characterization, when the content of graphene was 1 wt% of β-TCP, the G-β-TCP scaffold had the highest compression strength (127.25 MPa). And core–shell G-β-TCP-Ag-HAp not only had reduced cytotoxicity via the continuous release of Ag(+), but it also achieved long-term antibacterial properties. Besides, the material still showed good cell activity and proliferation. |
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