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The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties

Porous β-tricalcium phosphate (β-Ca(3)(PO(4))(2), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their...

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Autores principales: Qin, Long, Yi, Jiang, Xuefei, Lai, Li, Liao, Kenan, Xie, Lu, Xie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055648/
https://www.ncbi.nlm.nih.gov/pubmed/35519120
http://dx.doi.org/10.1039/d0ra02388d
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author Qin, Long
Yi, Jiang
Xuefei, Lai
Li, Liao
Kenan, Xie
Lu, Xie
author_facet Qin, Long
Yi, Jiang
Xuefei, Lai
Li, Liao
Kenan, Xie
Lu, Xie
author_sort Qin, Long
collection PubMed
description Porous β-tricalcium phosphate (β-Ca(3)(PO(4))(2), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method. In the synthesis process, G-β-TCP was prepared via an in situ synthesis method, and then silver nanoparticles and HAp particles were coated on the surface of the G-β-TCP scaffold in an orderly fashion using dopamine as a binder. From the results of characterization, when the content of graphene was 1 wt% of β-TCP, the G-β-TCP scaffold had the highest compression strength (127.25 MPa). And core–shell G-β-TCP-Ag-HAp not only had reduced cytotoxicity via the continuous release of Ag(+), but it also achieved long-term antibacterial properties. Besides, the material still showed good cell activity and proliferation.
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spelling pubmed-90556482022-05-04 The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties Qin, Long Yi, Jiang Xuefei, Lai Li, Liao Kenan, Xie Lu, Xie RSC Adv Chemistry Porous β-tricalcium phosphate (β-Ca(3)(PO(4))(2), β-TCP) scaffolds are widely applied in the field of bone tissue engineering due to their nontoxicity, degradability, biocompatibility, and osteoinductivity. However, poor compressive strength and a lack of antibacterial properties have hindered their clinical application. In order to address these disadvantages, graphene (G) and silver nanoparticles were introduced into β-TCP through a two-step method. In the synthesis process, G-β-TCP was prepared via an in situ synthesis method, and then silver nanoparticles and HAp particles were coated on the surface of the G-β-TCP scaffold in an orderly fashion using dopamine as a binder. From the results of characterization, when the content of graphene was 1 wt% of β-TCP, the G-β-TCP scaffold had the highest compression strength (127.25 MPa). And core–shell G-β-TCP-Ag-HAp not only had reduced cytotoxicity via the continuous release of Ag(+), but it also achieved long-term antibacterial properties. Besides, the material still showed good cell activity and proliferation. The Royal Society of Chemistry 2020-07-30 /pmc/articles/PMC9055648/ /pubmed/35519120 http://dx.doi.org/10.1039/d0ra02388d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Qin, Long
Yi, Jiang
Xuefei, Lai
Li, Liao
Kenan, Xie
Lu, Xie
The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title_full The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title_fullStr The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title_full_unstemmed The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title_short The preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
title_sort preparation of a difunctional porous β-tricalcium phosphate scaffold with excellent compressive strength and antibacterial properties
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055648/
https://www.ncbi.nlm.nih.gov/pubmed/35519120
http://dx.doi.org/10.1039/d0ra02388d
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