Cargando…

NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine

BACKGROUND: This review systematically summarizes gene biology features and protein structure of nucleoplasmin2 (NPM2) and the relationship between NPM2 and malignant peritoneal mesothelioma (MPM), in order to explore the molecular pathological mechanism of MPM and explore new therapeutic targets. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, He-liang, Yang, Zhi-ran, Yan, Li-jun, Su, Yan-dong, Ma, Ru, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055711/
https://www.ncbi.nlm.nih.gov/pubmed/35490253
http://dx.doi.org/10.1186/s12957-022-02604-3
_version_ 1784697475305570304
author Wu, He-liang
Yang, Zhi-ran
Yan, Li-jun
Su, Yan-dong
Ma, Ru
Li, Yan
author_facet Wu, He-liang
Yang, Zhi-ran
Yan, Li-jun
Su, Yan-dong
Ma, Ru
Li, Yan
author_sort Wu, He-liang
collection PubMed
description BACKGROUND: This review systematically summarizes gene biology features and protein structure of nucleoplasmin2 (NPM2) and the relationship between NPM2 and malignant peritoneal mesothelioma (MPM), in order to explore the molecular pathological mechanism of MPM and explore new therapeutic targets. METHODS: NCBI PubMed database was used for the literature search. NCBI Gene and Protein databases, Ensembl Genome Browser, UniProt, and RCSB PDB database were used for gene and protein review. Three online tools (Consurf, DoGSiteScorer, and ZdockServer), the GEPIA database, and the Cancer Genome Atlas were used to analyze bioinformatics characteristics for NPM2 protein. RESULTS: The main structural domains of NPM2 protein include the N-terminal core region, acidic region, and motif and disordered region. The N-terminal core region, involved in histone binding, is the most conserved domain in the nucleoplasmin (NPM) family. NPM2 with a large acidic tract in its C-terminal tail (NPM2-A2) is able to bind histones and form large complexes. Bioinformatics results indicated that NPM2 expression was correlated with the pathology of multiple tumors. Among mesothelioma patients, 5-year survival of patients with low-NPM2-expression was significantly higher than that of the high-NPM2-expression patients. NPM2 can facilitate the formation of histone deacetylation. NPM2 may promote histone deacetylation and inhibit the related-gene transcription, thus leading to abnormal proliferation, invasion, and metastasis of MPM. CONCLUSION: NPM2 may play a key role in the development and progression of MPM.
format Online
Article
Text
id pubmed-9055711
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-90557112022-05-01 NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine Wu, He-liang Yang, Zhi-ran Yan, Li-jun Su, Yan-dong Ma, Ru Li, Yan World J Surg Oncol Review BACKGROUND: This review systematically summarizes gene biology features and protein structure of nucleoplasmin2 (NPM2) and the relationship between NPM2 and malignant peritoneal mesothelioma (MPM), in order to explore the molecular pathological mechanism of MPM and explore new therapeutic targets. METHODS: NCBI PubMed database was used for the literature search. NCBI Gene and Protein databases, Ensembl Genome Browser, UniProt, and RCSB PDB database were used for gene and protein review. Three online tools (Consurf, DoGSiteScorer, and ZdockServer), the GEPIA database, and the Cancer Genome Atlas were used to analyze bioinformatics characteristics for NPM2 protein. RESULTS: The main structural domains of NPM2 protein include the N-terminal core region, acidic region, and motif and disordered region. The N-terminal core region, involved in histone binding, is the most conserved domain in the nucleoplasmin (NPM) family. NPM2 with a large acidic tract in its C-terminal tail (NPM2-A2) is able to bind histones and form large complexes. Bioinformatics results indicated that NPM2 expression was correlated with the pathology of multiple tumors. Among mesothelioma patients, 5-year survival of patients with low-NPM2-expression was significantly higher than that of the high-NPM2-expression patients. NPM2 can facilitate the formation of histone deacetylation. NPM2 may promote histone deacetylation and inhibit the related-gene transcription, thus leading to abnormal proliferation, invasion, and metastasis of MPM. CONCLUSION: NPM2 may play a key role in the development and progression of MPM. BioMed Central 2022-04-30 /pmc/articles/PMC9055711/ /pubmed/35490253 http://dx.doi.org/10.1186/s12957-022-02604-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, He-liang
Yang, Zhi-ran
Yan, Li-jun
Su, Yan-dong
Ma, Ru
Li, Yan
NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title_full NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title_fullStr NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title_full_unstemmed NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title_short NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
title_sort npm2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055711/
https://www.ncbi.nlm.nih.gov/pubmed/35490253
http://dx.doi.org/10.1186/s12957-022-02604-3
work_keys_str_mv AT wuheliang npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine
AT yangzhiran npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine
AT yanlijun npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine
AT suyandong npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine
AT maru npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine
AT liyan npm2inmalignantperitonealmesotheliomafrombasictumorbiologytoclinicalmedicine