Oxygen-Free Days as an Outcome Measure in Clinical Trials of Therapies for COVID-19 and Other Causes of New-Onset Hypoxemia

Mortality historically has been the primary outcome of choice for acute and critical care clinical trials. However, undue reliance on mortality can limit the scope of trials that can be performed. Large sample sizes are usually needed for trials powered for a mortality outcome, and focusing solely o...

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Detalles Bibliográficos
Autores principales: Moskowitz, Ari, Shotwell, Matthew S., Gibbs, Kevin W., Harkins, Michelle, Rosenberg, Yves, Troendle, James, Merck, Lisa H., Files, D. Clark, de Wit, Marjolein, Hudock, Kristin, Thompson, B. Taylor, Gong, Michelle N., Ginde, Adit A., Douin, David J., Brown, Samuel M., Rubin, Eileen, Joly, Meghan Morrison, Wang, Li, Lindsell, Christopher J., Bernard, Gordon R., Semler, Matthew W., Collins, Sean P., Self, Wesley H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American College of Chest Physicians. Published by Elsevier Inc. 2022
Materias:
Critical Care: Special Features
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055785/
https://www.ncbi.nlm.nih.gov/pubmed/35504307
http://dx.doi.org/10.1016/j.chest.2022.04.145

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