A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest

Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiratero...

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Detalles Bibliográficos
Autores principales: Lee, Dae Hyun, Money, David B, Deshpande, Akshay, Samuels, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055788/
https://www.ncbi.nlm.nih.gov/pubmed/35505742
http://dx.doi.org/10.7759/cureus.23678
Descripción
Sumario:Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiraterone-related hypokalemia which led to torsades de pointes (TdP) and ventricular fibrillation (VF). We reviewed the literature and showed the need for close monitoring of the potassium level and electrocardiogram (ECG) to prevent fatal arrhythmias.

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