A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest

Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiratero...

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Detalles Bibliográficos
Autores principales: Lee, Dae Hyun, Money, David B, Deshpande, Akshay, Samuels, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055788/
https://www.ncbi.nlm.nih.gov/pubmed/35505742
http://dx.doi.org/10.7759/cureus.23678
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author Lee, Dae Hyun
Money, David B
Deshpande, Akshay
Samuels, Brian
author_facet Lee, Dae Hyun
Money, David B
Deshpande, Akshay
Samuels, Brian
author_sort Lee, Dae Hyun
collection PubMed
description Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiraterone-related hypokalemia which led to torsades de pointes (TdP) and ventricular fibrillation (VF). We reviewed the literature and showed the need for close monitoring of the potassium level and electrocardiogram (ECG) to prevent fatal arrhythmias.
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spelling pubmed-90557882022-05-02 A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest Lee, Dae Hyun Money, David B Deshpande, Akshay Samuels, Brian Cureus Cardiology Abiraterone acetate is an androgen-depriving therapy (ADT) that is highly effective for treating castration-resistant prostate cancer (CRPC). By inhibiting CYP17, abiraterone can induce a state of mineralocorticoid excess, which is associated with profound hypokalemia. We present a case of abiraterone-related hypokalemia which led to torsades de pointes (TdP) and ventricular fibrillation (VF). We reviewed the literature and showed the need for close monitoring of the potassium level and electrocardiogram (ECG) to prevent fatal arrhythmias. Cureus 2022-03-31 /pmc/articles/PMC9055788/ /pubmed/35505742 http://dx.doi.org/10.7759/cureus.23678 Text en Copyright © 2022, Lee et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Lee, Dae Hyun
Money, David B
Deshpande, Akshay
Samuels, Brian
A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title_full A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title_fullStr A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title_full_unstemmed A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title_short A Case of Abiraterone-Related Hypokalemia Leading to Torsades de Pointes and Cardiac Arrest
title_sort case of abiraterone-related hypokalemia leading to torsades de pointes and cardiac arrest
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055788/
https://www.ncbi.nlm.nih.gov/pubmed/35505742
http://dx.doi.org/10.7759/cureus.23678
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