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Sensitivity enhancement of DHR123 radio-fluorogenic nanoclay gel dosimeter by incorporating surfactants and halogenides
Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials is particularly important for cancer radiotherapy. Here, we describe a radio-fluorogenic gel-based dosimeter that has achieved 16 times higher sensitivity by incorporating surfactants and halogenides. The gel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055799/ https://www.ncbi.nlm.nih.gov/pubmed/35520075 http://dx.doi.org/10.1039/d0ra02717k |
Sumario: | Dosimetry of spatial dose distribution of ionizing radiation in tissue equivalent materials is particularly important for cancer radiotherapy. Here, we describe a radio-fluorogenic gel-based dosimeter that has achieved 16 times higher sensitivity by incorporating surfactants and halogenides. The gel dosimeters were prepared from dihydrorhodamine 123 (DHR123) and small amounts of nano-sized clay and a radiosensitizer. By comprehensively changing the type of additives for the sensitizer (three surfactants: Triton X-100, sodium dodecyl sulfate (SDS) and cetyltrimethylammonium bromide, and three halogenides: trichloroacetic acid, tribromoacetic acid and 2,2,2-trichloroethanol), the increase in sensitivity can be explained by an increase in relative fluorescence quantum yield and an increase in radiation chemical yield. These highly sensitive gel dosimeters also show dose rate independent sensitivity under irradiation at 0.64 and 0.77 Gy min(−1) using a 6 MV X-ray therapeutic beam from the medical linac. |
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