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Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases

A valid option to bypass the obstacle represented by the blood–brain barrier (BBB) in brain delivery is the use of the unconventional intranasal route of administration. The treatment of depressive diseases, resulting from the depletion of a neurotransmitter in the inter-synaptic space, such as sero...

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Detalles Bibliográficos
Autores principales: Sorrentino, Alessandro, Cataldo, Antonino, Curatolo, Riccardo, Tagliatesta, Pietro, Mosca, Luciana, Bellucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055835/
https://www.ncbi.nlm.nih.gov/pubmed/35520064
http://dx.doi.org/10.1039/d0ra04212a
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author Sorrentino, Alessandro
Cataldo, Antonino
Curatolo, Riccardo
Tagliatesta, Pietro
Mosca, Luciana
Bellucci, Stefano
author_facet Sorrentino, Alessandro
Cataldo, Antonino
Curatolo, Riccardo
Tagliatesta, Pietro
Mosca, Luciana
Bellucci, Stefano
author_sort Sorrentino, Alessandro
collection PubMed
description A valid option to bypass the obstacle represented by the blood–brain barrier (BBB) in brain delivery is the use of the unconventional intranasal route of administration. The treatment of depressive diseases, resulting from the depletion of a neurotransmitter in the inter-synaptic space, such as serotonin, is indirectly treated using molecules that can permeate the BBB unlike the latter. In the present article, a set of nanovectors were produced using a mucoadhesive biopolymer, i.e. alginate (Alg). Optimizing the reaction, polymeric nanoparticles having diameter of 30–70 nm were produced, and water stable multi-walled carbon nanotubes functionalized (MWCNT-COOH)/Alg complexes were obtained. These nanovectors were loaded with serotonin, evaluating drug loading/release. By means of Raman microscopy, the cellular internalization of the (MWCNT-COOH)/Alg complex was demonstrated. A complete biocompatibility on neuronal cells was proved for the whole set of nanovectors. Finally, a method of self-administration was tested, which involves the use of a household apparatus, such as an aerosol machine, observing a fine particulate, able to deliver the nanovectors through the nose.
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spelling pubmed-90558352022-05-04 Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases Sorrentino, Alessandro Cataldo, Antonino Curatolo, Riccardo Tagliatesta, Pietro Mosca, Luciana Bellucci, Stefano RSC Adv Chemistry A valid option to bypass the obstacle represented by the blood–brain barrier (BBB) in brain delivery is the use of the unconventional intranasal route of administration. The treatment of depressive diseases, resulting from the depletion of a neurotransmitter in the inter-synaptic space, such as serotonin, is indirectly treated using molecules that can permeate the BBB unlike the latter. In the present article, a set of nanovectors were produced using a mucoadhesive biopolymer, i.e. alginate (Alg). Optimizing the reaction, polymeric nanoparticles having diameter of 30–70 nm were produced, and water stable multi-walled carbon nanotubes functionalized (MWCNT-COOH)/Alg complexes were obtained. These nanovectors were loaded with serotonin, evaluating drug loading/release. By means of Raman microscopy, the cellular internalization of the (MWCNT-COOH)/Alg complex was demonstrated. A complete biocompatibility on neuronal cells was proved for the whole set of nanovectors. Finally, a method of self-administration was tested, which involves the use of a household apparatus, such as an aerosol machine, observing a fine particulate, able to deliver the nanovectors through the nose. The Royal Society of Chemistry 2020-08-04 /pmc/articles/PMC9055835/ /pubmed/35520064 http://dx.doi.org/10.1039/d0ra04212a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Sorrentino, Alessandro
Cataldo, Antonino
Curatolo, Riccardo
Tagliatesta, Pietro
Mosca, Luciana
Bellucci, Stefano
Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title_full Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title_fullStr Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title_full_unstemmed Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title_short Novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
title_sort novel optimized biopolymer-based nanoparticles for nose-to-brain delivery in the treatment of depressive diseases
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055835/
https://www.ncbi.nlm.nih.gov/pubmed/35520064
http://dx.doi.org/10.1039/d0ra04212a
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