A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells

The hydroxyl radical (˙OH) has been suggested to play very vital roles in many physiological and pathological processes. However, selective detection of ˙OH is highly challenging owing to its extremely high reactivity and short lifetime. Herein, we designed and synthesized a sensitive “turn on” fluo...

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Detalles Bibliográficos
Autores principales: Qu, Xingyu, Bian, Yongjun, Chen, Yongqiang, Wei, Xiaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055842/
https://www.ncbi.nlm.nih.gov/pubmed/35520039
http://dx.doi.org/10.1039/d0ra05378c
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author Qu, Xingyu
Bian, Yongjun
Chen, Yongqiang
Wei, Xiaoqing
author_facet Qu, Xingyu
Bian, Yongjun
Chen, Yongqiang
Wei, Xiaoqing
author_sort Qu, Xingyu
collection PubMed
description The hydroxyl radical (˙OH) has been suggested to play very vital roles in many physiological and pathological processes. However, selective detection of ˙OH is highly challenging owing to its extremely high reactivity and short lifetime. Herein, we designed and synthesized a sensitive “turn on” fluorescent probe for detecting endogenous ˙OH based on a BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) platform. The probe had shown good properties including high sensitively, ideal selectively and low cytotoxicity, and was successfully employed to image endogenous hydroxyl radical in living cells.
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spelling pubmed-90558422022-05-04 A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells Qu, Xingyu Bian, Yongjun Chen, Yongqiang Wei, Xiaoqing RSC Adv Chemistry The hydroxyl radical (˙OH) has been suggested to play very vital roles in many physiological and pathological processes. However, selective detection of ˙OH is highly challenging owing to its extremely high reactivity and short lifetime. Herein, we designed and synthesized a sensitive “turn on” fluorescent probe for detecting endogenous ˙OH based on a BODIPY (4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) platform. The probe had shown good properties including high sensitively, ideal selectively and low cytotoxicity, and was successfully employed to image endogenous hydroxyl radical in living cells. The Royal Society of Chemistry 2020-08-04 /pmc/articles/PMC9055842/ /pubmed/35520039 http://dx.doi.org/10.1039/d0ra05378c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Qu, Xingyu
Bian, Yongjun
Chen, Yongqiang
Wei, Xiaoqing
A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title_full A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title_fullStr A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title_full_unstemmed A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title_short A sensitive BODIPY-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
title_sort sensitive bodipy-based fluorescent probe for detecting endogenous hydroxyl radicals in living cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055842/
https://www.ncbi.nlm.nih.gov/pubmed/35520039
http://dx.doi.org/10.1039/d0ra05378c
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