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eIF3a‐PPP2R5A‐mediated ATM/ATR dephosphorylation is essential for irinotecan‐induced DNA damage response

OBJECTIVES: The individual differences and pervasive resistance seriously hinder the optimization of irinotecan‐based therapeutic effectiveness. Eukaryotic translation initiation factor 3a (eIF3a) plays a key role in tumour occurrence, prognosis and therapeutic response. This study focused on the ro...

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Detalles Bibliográficos
Autores principales:	Mei, Chao, Sun, Ze‐En, Tan, Li‐Ming, Gong, Jian‐Ping, Li, Xi, Liu, Zhao‐Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055905/ https://www.ncbi.nlm.nih.gov/pubmed/35187743 http://dx.doi.org/10.1111/cpr.13208

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