Stereoselective synthesis of Gly-Gly-type (E)-methylalkene and (Z)-chloroalkene dipeptide isosteres and their application to 14-mer RGG peptidomimetics

Stereoselective and efficient synthesis of Gly-Gly-type (E)-methylalkene and (Z)-chloroalkene dipeptide isosteres is realized by organocuprate-mediated single electron transfer reduction. The synthetic isosteres can be used in Fmoc-based solid phase peptide synthesis, resulting in the preparation of...

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Detalles Bibliográficos
Autores principales: Okita, Hikari, Kato, Yuna, Masuzawa, Tatsuki, Arai, Kosuke, Takeo, Sayuri, Sato, Kohei, Mase, Nobuyuki, Oyoshi, Takanori, Narumi, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055925/
https://www.ncbi.nlm.nih.gov/pubmed/35521116
http://dx.doi.org/10.1039/d0ra06554d

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