Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors

Herein, we report an eco-friendly synthesis of a new series of quinazolinone-based derivatives as potential PARP-1 inhibitors. The 4-quinazolinone scaffold was utilized as a bioisostere to the phthalazinone core of the reference compound Olaparib. Most of the synthesized compounds displayed apprecia...

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Detalles Bibliográficos
Autores principales: Ramadan, Sayed K., Elrazaz, Eman Z., Abouzid, Khaled A. M., El-Naggar, Abeer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055986/
https://www.ncbi.nlm.nih.gov/pubmed/35521104
http://dx.doi.org/10.1039/d0ra05943a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055986/
https://www.ncbi.nlm.nih.gov/pubmed/35521104
http://dx.doi.org/10.1039/d0ra05943a

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