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Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors
Herein, we report an eco-friendly synthesis of a new series of quinazolinone-based derivatives as potential PARP-1 inhibitors. The 4-quinazolinone scaffold was utilized as a bioisostere to the phthalazinone core of the reference compound Olaparib. Most of the synthesized compounds displayed apprecia...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9055986/ https://www.ncbi.nlm.nih.gov/pubmed/35521104 http://dx.doi.org/10.1039/d0ra05943a |