Dexmedetomidine Activates Akt, STAT6 and IRF4 Modulating Cytoprotection and Macrophage Anti-Inflammatory Phenotype Against Acute Lung Injury in vivo and in vitro

PURPOSE: This study aims to investigate the cytoprotective and anti-inflammatory effects of an α(2)-adrenoreceptor (α(2)-AR) agonist, dexmedetomidine (Dex), on lipopolysaccharides (LPS)-induced acute lung injury and underlying mechanisms with focus on alveolar macrophage polarization modulation. MET...

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Detalles Bibliográficos
Autores principales: Chen, Qian, Qin, Zhigang, Sun, Yibing, Liu, Xiangfeng, Pac Soo, Aurelie, Chang, Enqiang, Sun, Qizhe, Yi, Bin, Wang, Dong-Xin, Zhao, Hailin, Ma, Daqing, Gu, Jianteng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056075/
https://www.ncbi.nlm.nih.gov/pubmed/35502244
http://dx.doi.org/10.2147/JIR.S357012

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