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Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage

BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive v...

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Autores principales: Luo, Cong, Yao, Jiaxin, Bi, Haoran, Li, Zhen, Li, Ju, Xue, Guosong, Li, Ke, Zhang, Shenyang, Zan, Kun, Meng, Wenqing, Zhang, Zunsheng, Chen, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056097/
https://www.ncbi.nlm.nih.gov/pubmed/35502188
http://dx.doi.org/10.2147/CIA.S362854
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author Luo, Cong
Yao, Jiaxin
Bi, Haoran
Li, Zhen
Li, Ju
Xue, Guosong
Li, Ke
Zhang, Shenyang
Zan, Kun
Meng, Wenqing
Zhang, Zunsheng
Chen, Hao
author_facet Luo, Cong
Yao, Jiaxin
Bi, Haoran
Li, Zhen
Li, Ju
Xue, Guosong
Li, Ke
Zhang, Shenyang
Zan, Kun
Meng, Wenqing
Zhang, Zunsheng
Chen, Hao
author_sort Luo, Cong
collection PubMed
description BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive value for prognosis. METHODS: In this retrospective study, 206 patients with aSAH were recruited and assigned to a severe group (WFNS grade ≥ 4) and a mild group (WFNS grade < 4) according to the severity of patients on admission. Flow cytometry was performed to detect the levels of 12 inflammatory cytokines in the serum of patients. Then, patients were grouped into a poor prognosis group (mRS score ≥ 4) and a good prognosis group (mRS score < 4) based on their prognosis after 3 months of discharge to compare the relationship between cytokines and prognosis. Propensity score matching (PSM) was utilized to control confounding factors. The correlation between inflammatory factors and prognosis was determined using Spearman correlation, and the predictive efficacy of inflammatory factors was tested by a receiver operating characteristic curve. RESULTS: Serum IL-1β, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α levels were significantly higher in the mild group than in the severe group and in the poor prognosis group than in the good prognosis group. After PSM, the differences in IL-1β, IL-5, IFN-α, and IFN-γ levels disappeared between the two groups, whereas IL-2, IL-6, IL-8, IL-10, and TNF-α levels remained higher in the poor prognosis group than in the good prognosis group. Additionally, IL-2, IL-6, IL-8, and IL-10 levels were positively correlated with mRS scores. Moreover, the predictive value was found to be the highest for IL-6 and the lowest for TNF-α. CONCLUSION: Inflammation degree was related to the severity of aSAH. Inflammatory markers, including IL-6, IL-10, IL-8, IL-2, and TNF-α, might predict the poor prognosis of aSAH.
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spelling pubmed-90560972022-05-01 Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage Luo, Cong Yao, Jiaxin Bi, Haoran Li, Zhen Li, Ju Xue, Guosong Li, Ke Zhang, Shenyang Zan, Kun Meng, Wenqing Zhang, Zunsheng Chen, Hao Clin Interv Aging Original Research BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive value for prognosis. METHODS: In this retrospective study, 206 patients with aSAH were recruited and assigned to a severe group (WFNS grade ≥ 4) and a mild group (WFNS grade < 4) according to the severity of patients on admission. Flow cytometry was performed to detect the levels of 12 inflammatory cytokines in the serum of patients. Then, patients were grouped into a poor prognosis group (mRS score ≥ 4) and a good prognosis group (mRS score < 4) based on their prognosis after 3 months of discharge to compare the relationship between cytokines and prognosis. Propensity score matching (PSM) was utilized to control confounding factors. The correlation between inflammatory factors and prognosis was determined using Spearman correlation, and the predictive efficacy of inflammatory factors was tested by a receiver operating characteristic curve. RESULTS: Serum IL-1β, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α levels were significantly higher in the mild group than in the severe group and in the poor prognosis group than in the good prognosis group. After PSM, the differences in IL-1β, IL-5, IFN-α, and IFN-γ levels disappeared between the two groups, whereas IL-2, IL-6, IL-8, IL-10, and TNF-α levels remained higher in the poor prognosis group than in the good prognosis group. Additionally, IL-2, IL-6, IL-8, and IL-10 levels were positively correlated with mRS scores. Moreover, the predictive value was found to be the highest for IL-6 and the lowest for TNF-α. CONCLUSION: Inflammation degree was related to the severity of aSAH. Inflammatory markers, including IL-6, IL-10, IL-8, IL-2, and TNF-α, might predict the poor prognosis of aSAH. Dove 2022-04-26 /pmc/articles/PMC9056097/ /pubmed/35502188 http://dx.doi.org/10.2147/CIA.S362854 Text en © 2022 Luo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Luo, Cong
Yao, Jiaxin
Bi, Haoran
Li, Zhen
Li, Ju
Xue, Guosong
Li, Ke
Zhang, Shenyang
Zan, Kun
Meng, Wenqing
Zhang, Zunsheng
Chen, Hao
Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title_full Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title_fullStr Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title_full_unstemmed Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title_short Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
title_sort clinical value of inflammatory cytokines in patients with aneurysmal subarachnoid hemorrhage
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056097/
https://www.ncbi.nlm.nih.gov/pubmed/35502188
http://dx.doi.org/10.2147/CIA.S362854
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