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Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage
BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive v...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056097/ https://www.ncbi.nlm.nih.gov/pubmed/35502188 http://dx.doi.org/10.2147/CIA.S362854 |
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author | Luo, Cong Yao, Jiaxin Bi, Haoran Li, Zhen Li, Ju Xue, Guosong Li, Ke Zhang, Shenyang Zan, Kun Meng, Wenqing Zhang, Zunsheng Chen, Hao |
author_facet | Luo, Cong Yao, Jiaxin Bi, Haoran Li, Zhen Li, Ju Xue, Guosong Li, Ke Zhang, Shenyang Zan, Kun Meng, Wenqing Zhang, Zunsheng Chen, Hao |
author_sort | Luo, Cong |
collection | PubMed |
description | BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive value for prognosis. METHODS: In this retrospective study, 206 patients with aSAH were recruited and assigned to a severe group (WFNS grade ≥ 4) and a mild group (WFNS grade < 4) according to the severity of patients on admission. Flow cytometry was performed to detect the levels of 12 inflammatory cytokines in the serum of patients. Then, patients were grouped into a poor prognosis group (mRS score ≥ 4) and a good prognosis group (mRS score < 4) based on their prognosis after 3 months of discharge to compare the relationship between cytokines and prognosis. Propensity score matching (PSM) was utilized to control confounding factors. The correlation between inflammatory factors and prognosis was determined using Spearman correlation, and the predictive efficacy of inflammatory factors was tested by a receiver operating characteristic curve. RESULTS: Serum IL-1β, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α levels were significantly higher in the mild group than in the severe group and in the poor prognosis group than in the good prognosis group. After PSM, the differences in IL-1β, IL-5, IFN-α, and IFN-γ levels disappeared between the two groups, whereas IL-2, IL-6, IL-8, IL-10, and TNF-α levels remained higher in the poor prognosis group than in the good prognosis group. Additionally, IL-2, IL-6, IL-8, and IL-10 levels were positively correlated with mRS scores. Moreover, the predictive value was found to be the highest for IL-6 and the lowest for TNF-α. CONCLUSION: Inflammation degree was related to the severity of aSAH. Inflammatory markers, including IL-6, IL-10, IL-8, IL-2, and TNF-α, might predict the poor prognosis of aSAH. |
format | Online Article Text |
id | pubmed-9056097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-90560972022-05-01 Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage Luo, Cong Yao, Jiaxin Bi, Haoran Li, Zhen Li, Ju Xue, Guosong Li, Ke Zhang, Shenyang Zan, Kun Meng, Wenqing Zhang, Zunsheng Chen, Hao Clin Interv Aging Original Research BACKGROUND: Inflammation is closely associated with prognosis in patients with aneurysmal subarachnoid hemorrhage (aSAH), which is orchestrated by inflammatory cytokines. Therefore, this study aimed to investigate the levels of inflammatory cytokines in the early stage of aSAH and their predictive value for prognosis. METHODS: In this retrospective study, 206 patients with aSAH were recruited and assigned to a severe group (WFNS grade ≥ 4) and a mild group (WFNS grade < 4) according to the severity of patients on admission. Flow cytometry was performed to detect the levels of 12 inflammatory cytokines in the serum of patients. Then, patients were grouped into a poor prognosis group (mRS score ≥ 4) and a good prognosis group (mRS score < 4) based on their prognosis after 3 months of discharge to compare the relationship between cytokines and prognosis. Propensity score matching (PSM) was utilized to control confounding factors. The correlation between inflammatory factors and prognosis was determined using Spearman correlation, and the predictive efficacy of inflammatory factors was tested by a receiver operating characteristic curve. RESULTS: Serum IL-1β, IL-5, IL-6, IL-8, IL-10, IFN-γ, and TNF-α levels were significantly higher in the mild group than in the severe group and in the poor prognosis group than in the good prognosis group. After PSM, the differences in IL-1β, IL-5, IFN-α, and IFN-γ levels disappeared between the two groups, whereas IL-2, IL-6, IL-8, IL-10, and TNF-α levels remained higher in the poor prognosis group than in the good prognosis group. Additionally, IL-2, IL-6, IL-8, and IL-10 levels were positively correlated with mRS scores. Moreover, the predictive value was found to be the highest for IL-6 and the lowest for TNF-α. CONCLUSION: Inflammation degree was related to the severity of aSAH. Inflammatory markers, including IL-6, IL-10, IL-8, IL-2, and TNF-α, might predict the poor prognosis of aSAH. Dove 2022-04-26 /pmc/articles/PMC9056097/ /pubmed/35502188 http://dx.doi.org/10.2147/CIA.S362854 Text en © 2022 Luo et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Luo, Cong Yao, Jiaxin Bi, Haoran Li, Zhen Li, Ju Xue, Guosong Li, Ke Zhang, Shenyang Zan, Kun Meng, Wenqing Zhang, Zunsheng Chen, Hao Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title | Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title_full | Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title_fullStr | Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title_full_unstemmed | Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title_short | Clinical Value of Inflammatory Cytokines in Patients with Aneurysmal Subarachnoid Hemorrhage |
title_sort | clinical value of inflammatory cytokines in patients with aneurysmal subarachnoid hemorrhage |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056097/ https://www.ncbi.nlm.nih.gov/pubmed/35502188 http://dx.doi.org/10.2147/CIA.S362854 |
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