Cargando…
Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent
A selective, sensitive, and environmentally safe spectrophotometry method was developed and validated for the determination of zinc in pharmaceutical substances using natural reagents obtained from the leaves of plant Acacia catechu. Different factors were optimized such as volume of reagent, select...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056243/ https://www.ncbi.nlm.nih.gov/pubmed/35502194 http://dx.doi.org/10.1155/2022/8520432 |
_version_ | 1784697592340283392 |
---|---|
author | Sharma, Hemraj Sharma, Arjun Sharma, Bimala Karna, Sonu |
author_facet | Sharma, Hemraj Sharma, Arjun Sharma, Bimala Karna, Sonu |
author_sort | Sharma, Hemraj |
collection | PubMed |
description | A selective, sensitive, and environmentally safe spectrophotometry method was developed and validated for the determination of zinc in pharmaceutical substances using natural reagents obtained from the leaves of plant Acacia catechu. Different factors were optimized such as volume of reagent, selection of pH, and stability of the color complex. The drug showed a stable yellowish orange color complex at 550 nm. The greenness of the methods was estimated using an eco-scale tool where the presented method was found to be excellent green with an ecoscore of 84 based on spectrophotometric determination. Also, the greenness of the method was assessed by the Green Analytical Procedure Index and found to be eco-friendly. The method was validated in conformance with ICH guidelines, with acceptable values for linearity, accuracy, precision, LOD, and LOQ. The linearity range for zinc sulphate was 5–25 μg mL(−1) with an R(2) value of 0.996. The % RSD for intraday precision and interday precision was less than 2%. The suggested method can be employed for the economic analysis of zinc in its pure form and various formulations. The presented spectrophotometric method is the first analytical method for the analysis of zinc present in zinc sulphate and showed greater ecoscale as compared to the official method. |
format | Online Article Text |
id | pubmed-9056243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90562432022-05-01 Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent Sharma, Hemraj Sharma, Arjun Sharma, Bimala Karna, Sonu Int J Anal Chem Research Article A selective, sensitive, and environmentally safe spectrophotometry method was developed and validated for the determination of zinc in pharmaceutical substances using natural reagents obtained from the leaves of plant Acacia catechu. Different factors were optimized such as volume of reagent, selection of pH, and stability of the color complex. The drug showed a stable yellowish orange color complex at 550 nm. The greenness of the methods was estimated using an eco-scale tool where the presented method was found to be excellent green with an ecoscore of 84 based on spectrophotometric determination. Also, the greenness of the method was assessed by the Green Analytical Procedure Index and found to be eco-friendly. The method was validated in conformance with ICH guidelines, with acceptable values for linearity, accuracy, precision, LOD, and LOQ. The linearity range for zinc sulphate was 5–25 μg mL(−1) with an R(2) value of 0.996. The % RSD for intraday precision and interday precision was less than 2%. The suggested method can be employed for the economic analysis of zinc in its pure form and various formulations. The presented spectrophotometric method is the first analytical method for the analysis of zinc present in zinc sulphate and showed greater ecoscale as compared to the official method. Hindawi 2022-04-23 /pmc/articles/PMC9056243/ /pubmed/35502194 http://dx.doi.org/10.1155/2022/8520432 Text en Copyright © 2022 Hemraj Sharma et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sharma, Hemraj Sharma, Arjun Sharma, Bimala Karna, Sonu Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title | Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title_full | Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title_fullStr | Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title_full_unstemmed | Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title_short | Green Analytical Approach for the Determination of Zinc in Pharmaceutical Product Using Natural Reagent |
title_sort | green analytical approach for the determination of zinc in pharmaceutical product using natural reagent |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056243/ https://www.ncbi.nlm.nih.gov/pubmed/35502194 http://dx.doi.org/10.1155/2022/8520432 |
work_keys_str_mv | AT sharmahemraj greenanalyticalapproachforthedeterminationofzincinpharmaceuticalproductusingnaturalreagent AT sharmaarjun greenanalyticalapproachforthedeterminationofzincinpharmaceuticalproductusingnaturalreagent AT sharmabimala greenanalyticalapproachforthedeterminationofzincinpharmaceuticalproductusingnaturalreagent AT karnasonu greenanalyticalapproachforthedeterminationofzincinpharmaceuticalproductusingnaturalreagent |