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Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease
Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic memory, working memory, and executive function. Semantic disfluency is a common problem in Parkinson's disease (PD) and Alzheimer's disease (AD). We demonstrated a graph theo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056264/ https://www.ncbi.nlm.nih.gov/pubmed/35502419 http://dx.doi.org/10.1155/2022/6935263 |
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author | Zhang, Guanyu Ma, Jinghong Chan, Piu Ye, Zheng |
author_facet | Zhang, Guanyu Ma, Jinghong Chan, Piu Ye, Zheng |
author_sort | Zhang, Guanyu |
collection | PubMed |
description | Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic memory, working memory, and executive function. Semantic disfluency is a common problem in Parkinson's disease (PD) and Alzheimer's disease (AD). We demonstrated a graph theoretical analysis of semantic fluency in patients with PD (N = 86), patients with AD (N = 40), and healthy controls (HC, N = 88). All participants completed a standard animal fluency test. Their verbal responses were recorded, transcripted, and transformed into directed speech graphs. Patients with PD generated fewer correct words than HC and more correct words than patients with AD. Patients with PD showed higher density, shorter diameter, and shorter average shortest path length than HC, but lower density, longer diameter, and longer average shortest path length than patients with AD. It suggests that patients with PD produced relatively smaller and denser speech graphs. Moreover, in PD, the densities of speech graphs correlated with the severity of non-motor symptoms, but not the severity of motor symptoms. The graph theoretical analysis revealed new features of semantic disfluency in patients with PD. |
format | Online Article Text |
id | pubmed-9056264 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-90562642022-05-01 Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease Zhang, Guanyu Ma, Jinghong Chan, Piu Ye, Zheng Behav Neurol Research Article Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic memory, working memory, and executive function. Semantic disfluency is a common problem in Parkinson's disease (PD) and Alzheimer's disease (AD). We demonstrated a graph theoretical analysis of semantic fluency in patients with PD (N = 86), patients with AD (N = 40), and healthy controls (HC, N = 88). All participants completed a standard animal fluency test. Their verbal responses were recorded, transcripted, and transformed into directed speech graphs. Patients with PD generated fewer correct words than HC and more correct words than patients with AD. Patients with PD showed higher density, shorter diameter, and shorter average shortest path length than HC, but lower density, longer diameter, and longer average shortest path length than patients with AD. It suggests that patients with PD produced relatively smaller and denser speech graphs. Moreover, in PD, the densities of speech graphs correlated with the severity of non-motor symptoms, but not the severity of motor symptoms. The graph theoretical analysis revealed new features of semantic disfluency in patients with PD. Hindawi 2022-04-23 /pmc/articles/PMC9056264/ /pubmed/35502419 http://dx.doi.org/10.1155/2022/6935263 Text en Copyright © 2022 Guanyu Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Guanyu Ma, Jinghong Chan, Piu Ye, Zheng Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title | Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title_full | Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title_fullStr | Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title_full_unstemmed | Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title_short | Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease |
title_sort | graph theoretical analysis of semantic fluency in patients with parkinson's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056264/ https://www.ncbi.nlm.nih.gov/pubmed/35502419 http://dx.doi.org/10.1155/2022/6935263 |
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