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A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF(2)COOEt as the difluoromethylation reagent

We describe a novel transition metal-free method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available ethyl bromodifluoroacetate as a fluorine source. The formation of N-difluoromethylated pyridines involves a two-step process in which N-alkylatio...

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Detalles Bibliográficos
Autores principales:	Gandioso, Albert, El Fakiri, Mohamed, Rovira, Anna, Marchán, Vicente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056270/ https://www.ncbi.nlm.nih.gov/pubmed/35518226 http://dx.doi.org/10.1039/d0ra06322c

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