Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F

Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate-l-rhamnose (dTDP-Rha) biosynthetic pathway. In this study, the broad substrate specificity of...

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Detalles Bibliográficos
Autores principales: Li, Siqiang, Wang, Hong, Jin, Guoxia, Chen, Zonggang, Gu, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056299/
https://www.ncbi.nlm.nih.gov/pubmed/35518267
http://dx.doi.org/10.1039/d0ra05799a
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author Li, Siqiang
Wang, Hong
Jin, Guoxia
Chen, Zonggang
Gu, Guofeng
author_facet Li, Siqiang
Wang, Hong
Jin, Guoxia
Chen, Zonggang
Gu, Guofeng
author_sort Li, Siqiang
collection PubMed
description Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate-l-rhamnose (dTDP-Rha) biosynthetic pathway. In this study, the broad substrate specificity of Cps23FL towards six glucose-1-phosphates and nine nucleoside triphosphates as substrates was systematically explored, eventually providing access to nineteen sugar nucleotide analogs.
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spelling pubmed-90562992022-05-04 Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F Li, Siqiang Wang, Hong Jin, Guoxia Chen, Zonggang Gu, Guofeng RSC Adv Chemistry Glucose-1-phosphate thymidylyltransferase (Cps23FL) from Streptococcus pneumonia serotype 23F is the initial enzyme that catalyses the thymidylyl transfer reaction in prokaryotic deoxythymidine diphosphate-l-rhamnose (dTDP-Rha) biosynthetic pathway. In this study, the broad substrate specificity of Cps23FL towards six glucose-1-phosphates and nine nucleoside triphosphates as substrates was systematically explored, eventually providing access to nineteen sugar nucleotide analogs. The Royal Society of Chemistry 2020-08-14 /pmc/articles/PMC9056299/ /pubmed/35518267 http://dx.doi.org/10.1039/d0ra05799a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Li, Siqiang
Wang, Hong
Jin, Guoxia
Chen, Zonggang
Gu, Guofeng
Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title_full Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title_fullStr Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title_full_unstemmed Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title_short Exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase Cps23FL from Streptococcus pneumonia serotype 23F
title_sort exploring the broad nucleotide triphosphate and sugar-1-phosphate specificity of thymidylyltransferase cps23fl from streptococcus pneumonia serotype 23f
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056299/
https://www.ncbi.nlm.nih.gov/pubmed/35518267
http://dx.doi.org/10.1039/d0ra05799a
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