MIDA boronate allylation – synthesis of ibuprofen

MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, in...

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Detalles Bibliográficos
Autores principales: Phillips, David, Brodie, Glen, Memarzadeh, Sarah, Tang, Gi Lum, France, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056333/
https://www.ncbi.nlm.nih.gov/pubmed/35516040
http://dx.doi.org/10.1039/d0ra03338c
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author Phillips, David
Brodie, Glen
Memarzadeh, Sarah
Tang, Gi Lum
France, David J.
author_facet Phillips, David
Brodie, Glen
Memarzadeh, Sarah
Tang, Gi Lum
France, David J.
author_sort Phillips, David
collection PubMed
description MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen.
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spelling pubmed-90563332022-05-04 MIDA boronate allylation – synthesis of ibuprofen Phillips, David Brodie, Glen Memarzadeh, Sarah Tang, Gi Lum France, David J. RSC Adv Chemistry MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen. The Royal Society of Chemistry 2020-08-18 /pmc/articles/PMC9056333/ /pubmed/35516040 http://dx.doi.org/10.1039/d0ra03338c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Phillips, David
Brodie, Glen
Memarzadeh, Sarah
Tang, Gi Lum
France, David J.
MIDA boronate allylation – synthesis of ibuprofen
title MIDA boronate allylation – synthesis of ibuprofen
title_full MIDA boronate allylation – synthesis of ibuprofen
title_fullStr MIDA boronate allylation – synthesis of ibuprofen
title_full_unstemmed MIDA boronate allylation – synthesis of ibuprofen
title_short MIDA boronate allylation – synthesis of ibuprofen
title_sort mida boronate allylation – synthesis of ibuprofen
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056333/
https://www.ncbi.nlm.nih.gov/pubmed/35516040
http://dx.doi.org/10.1039/d0ra03338c
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AT tanggilum midaboronateallylationsynthesisofibuprofen
AT francedavidj midaboronateallylationsynthesisofibuprofen

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