ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil

A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, boucha...

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Detalles Bibliográficos
Autores principales: Kim, Kyeongha, Kim, Hun Young, Oh, Kyungsoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056348/
https://www.ncbi.nlm.nih.gov/pubmed/35520643
http://dx.doi.org/10.1039/d0ra06820a
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author Kim, Kyeongha
Kim, Hun Young
Oh, Kyungsoo
author_facet Kim, Kyeongha
Kim, Hun Young
Oh, Kyungsoo
author_sort Kim, Kyeongha
collection PubMed
description A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner.
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spelling pubmed-90563482022-05-04 ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil Kim, Kyeongha Kim, Hun Young Oh, Kyungsoo RSC Adv Chemistry A facile access to fused pyrimidin-4(3H)-one derivatives has been established by using the metal-free ortho-naphthoquinone-catalyzed aerobic cross-coupling reactions of amines. The utilization of two readily available amines allowed a direct coupling strategy to quinazolinone natural product, bouchardatine, as well as sildenafil (Viagra™) in a highly convergent manner. The Royal Society of Chemistry 2020-08-21 /pmc/articles/PMC9056348/ /pubmed/35520643 http://dx.doi.org/10.1039/d0ra06820a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Kim, Kyeongha
Kim, Hun Young
Oh, Kyungsoo
ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title_full ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title_fullStr ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title_full_unstemmed ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title_short ortho-Naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3H)-ones: a convergent synthetic route to bouchardatine and sildenafil
title_sort ortho-naphthoquinone-catalyzed aerobic oxidation of amines to fused pyrimidin-4(3h)-ones: a convergent synthetic route to bouchardatine and sildenafil
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056348/
https://www.ncbi.nlm.nih.gov/pubmed/35520643
http://dx.doi.org/10.1039/d0ra06820a
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