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Synthesis and biological activity evaluation of azacycloheptane sulfonamide derivatives as potential orexin receptor antagonists

As the orexin signaling system is crucial for the regulation of the sleep/wake cycle, inhibitors of orexin-1 and orexin-2 receptors are of significant interest in the treatment of insomnia. Herein, a series of novel azacycloheptane sulfonamide derivatives were designed and synthesized, and all the c...

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Detalles Bibliográficos
Autores principales: Guo, Bin, Xiu, Jingya, Shen, Yi, Li, Qingeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056352/
https://www.ncbi.nlm.nih.gov/pubmed/35516053
http://dx.doi.org/10.1039/d0ra05068g

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