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Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone
A site-selective ruthenium-catalyzed keto group assisted C–H bond activation of 2-aryl tetrahydroquinoline (azaflavanone) derivatives has been achieved with a variety of alkenes for the first time. A wide range of substrates was utilized for the synthesis of a wide variety of alkenylated azaflavanon...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056431/ https://www.ncbi.nlm.nih.gov/pubmed/35520642 http://dx.doi.org/10.1039/d0ra06580c |
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author | Bakthadoss, Manickam Reddy, Tadiparthi Thirupathi Sharada, Duddu S. |
author_facet | Bakthadoss, Manickam Reddy, Tadiparthi Thirupathi Sharada, Duddu S. |
author_sort | Bakthadoss, Manickam |
collection | PubMed |
description | A site-selective ruthenium-catalyzed keto group assisted C–H bond activation of 2-aryl tetrahydroquinoline (azaflavanone) derivatives has been achieved with a variety of alkenes for the first time. A wide range of substrates was utilized for the synthesis of a wide variety of alkenylated azaflavanones. This simple and efficient protocol provides the C5-substituted azaflavanone derivatives in high yields with a broad range of functional group tolerance. Further, the C5-alkenylated products were converted into substituted 2-aryl quinoline derivatives in good yields. |
format | Online Article Text |
id | pubmed-9056431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-90564312022-05-04 Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone Bakthadoss, Manickam Reddy, Tadiparthi Thirupathi Sharada, Duddu S. RSC Adv Chemistry A site-selective ruthenium-catalyzed keto group assisted C–H bond activation of 2-aryl tetrahydroquinoline (azaflavanone) derivatives has been achieved with a variety of alkenes for the first time. A wide range of substrates was utilized for the synthesis of a wide variety of alkenylated azaflavanones. This simple and efficient protocol provides the C5-substituted azaflavanone derivatives in high yields with a broad range of functional group tolerance. Further, the C5-alkenylated products were converted into substituted 2-aryl quinoline derivatives in good yields. The Royal Society of Chemistry 2020-08-26 /pmc/articles/PMC9056431/ /pubmed/35520642 http://dx.doi.org/10.1039/d0ra06580c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Bakthadoss, Manickam Reddy, Tadiparthi Thirupathi Sharada, Duddu S. Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title | Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title_full | Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title_fullStr | Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title_full_unstemmed | Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title_short | Ruthenium-catalyzed, site-selective C–H activation: access to C5-substituted azaflavanone |
title_sort | ruthenium-catalyzed, site-selective c–h activation: access to c5-substituted azaflavanone |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056431/ https://www.ncbi.nlm.nih.gov/pubmed/35520642 http://dx.doi.org/10.1039/d0ra06580c |
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