Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation

A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds via tandem cyclization of o-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to or...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Yao, Shijie, Wang, Chaoli, Zhang, Yahui, Hao, Wenyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056576/
https://www.ncbi.nlm.nih.gov/pubmed/35518184
http://dx.doi.org/10.1039/d0ra06671k
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author Liu, Yang
Yao, Shijie
Wang, Chaoli
Zhang, Yahui
Hao, Wenyan
author_facet Liu, Yang
Yao, Shijie
Wang, Chaoli
Zhang, Yahui
Hao, Wenyan
author_sort Liu, Yang
collection PubMed
description A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds via tandem cyclization of o-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus heterocycles in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus providing a potential application of this cascade cyclization strategy in synthesis.
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spelling pubmed-90565762022-05-04 Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation Liu, Yang Yao, Shijie Wang, Chaoli Zhang, Yahui Hao, Wenyan RSC Adv Chemistry A copper(ii)-catalyzed, high-efficiency and atom-economical synthesis of valuable organophosphorus compounds via tandem cyclization of o-alkynylphenyl isothiocyanates with phosphites is described. This protocol, having a good functional-group compatibility, provides a simple and direct pathway to organophosphorus heterocycles in good yields under mild conditions. The method could be efficiently scaled up to gram scale, thus providing a potential application of this cascade cyclization strategy in synthesis. The Royal Society of Chemistry 2020-09-01 /pmc/articles/PMC9056576/ /pubmed/35518184 http://dx.doi.org/10.1039/d0ra06671k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Liu, Yang
Yao, Shijie
Wang, Chaoli
Zhang, Yahui
Hao, Wenyan
Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title_full Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title_fullStr Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title_full_unstemmed Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title_short Copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving C–P and C–S bond formation
title_sort copper(ii)-catalyzed tandem cyclization for the synthesis of benzo[d][1,3]thiazin-2-yl phosphonates involving c–p and c–s bond formation
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056576/
https://www.ncbi.nlm.nih.gov/pubmed/35518184
http://dx.doi.org/10.1039/d0ra06671k
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