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Closed-loop enhancement and neural decoding of cognitive control in humans

Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial e...

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Autores principales: Basu, Ishita, Yousefi, Ali, Crocker, Britni, Zelmann, Rina, Paulk, Angelique C, Peled, Noam, Ellard, Kristen K, Weisholtz, Daniel S, Cosgrove, G. Rees, Deckersbach, Thilo, Eden, Uri T, Eskandar, Emad N, Dougherty, Darin D, Cash, Sydney S, Widge, Alik S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056584/
https://www.ncbi.nlm.nih.gov/pubmed/34725508
http://dx.doi.org/10.1038/s41551-021-00804-y
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author Basu, Ishita
Yousefi, Ali
Crocker, Britni
Zelmann, Rina
Paulk, Angelique C
Peled, Noam
Ellard, Kristen K
Weisholtz, Daniel S
Cosgrove, G. Rees
Deckersbach, Thilo
Eden, Uri T
Eskandar, Emad N
Dougherty, Darin D
Cash, Sydney S
Widge, Alik S
author_facet Basu, Ishita
Yousefi, Ali
Crocker, Britni
Zelmann, Rina
Paulk, Angelique C
Peled, Noam
Ellard, Kristen K
Weisholtz, Daniel S
Cosgrove, G. Rees
Deckersbach, Thilo
Eden, Uri T
Eskandar, Emad N
Dougherty, Darin D
Cash, Sydney S
Widge, Alik S
author_sort Basu, Ishita
collection PubMed
description Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants’ cognitive control during a conflict task. We also show that closed-loop stimulation upon the detection of lapses in cognitive control produced larger behavioural changes than open-loop stimulation, and that task performance for single trials can be directly decoded from the activity of a small number of electrodes, via neural features that are compatible with existing closed-loop brain implants. Closed-loop enhancement of cognitive control might remediate underlying cognitive deficits and aid the treatment of severe mental disorders.
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spelling pubmed-90565842023-04-29 Closed-loop enhancement and neural decoding of cognitive control in humans Basu, Ishita Yousefi, Ali Crocker, Britni Zelmann, Rina Paulk, Angelique C Peled, Noam Ellard, Kristen K Weisholtz, Daniel S Cosgrove, G. Rees Deckersbach, Thilo Eden, Uri T Eskandar, Emad N Dougherty, Darin D Cash, Sydney S Widge, Alik S Nat Biomed Eng Article Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants’ cognitive control during a conflict task. We also show that closed-loop stimulation upon the detection of lapses in cognitive control produced larger behavioural changes than open-loop stimulation, and that task performance for single trials can be directly decoded from the activity of a small number of electrodes, via neural features that are compatible with existing closed-loop brain implants. Closed-loop enhancement of cognitive control might remediate underlying cognitive deficits and aid the treatment of severe mental disorders. 2023-04 2021-11-01 /pmc/articles/PMC9056584/ /pubmed/34725508 http://dx.doi.org/10.1038/s41551-021-00804-y Text en Reprints and permissions information is available at www.nature.com/reprints (http://www.nature.com/reprints) . Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Basu, Ishita
Yousefi, Ali
Crocker, Britni
Zelmann, Rina
Paulk, Angelique C
Peled, Noam
Ellard, Kristen K
Weisholtz, Daniel S
Cosgrove, G. Rees
Deckersbach, Thilo
Eden, Uri T
Eskandar, Emad N
Dougherty, Darin D
Cash, Sydney S
Widge, Alik S
Closed-loop enhancement and neural decoding of cognitive control in humans
title Closed-loop enhancement and neural decoding of cognitive control in humans
title_full Closed-loop enhancement and neural decoding of cognitive control in humans
title_fullStr Closed-loop enhancement and neural decoding of cognitive control in humans
title_full_unstemmed Closed-loop enhancement and neural decoding of cognitive control in humans
title_short Closed-loop enhancement and neural decoding of cognitive control in humans
title_sort closed-loop enhancement and neural decoding of cognitive control in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056584/
https://www.ncbi.nlm.nih.gov/pubmed/34725508
http://dx.doi.org/10.1038/s41551-021-00804-y
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