Cargando…
Closed-loop enhancement and neural decoding of cognitive control in humans
Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial e...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056584/ https://www.ncbi.nlm.nih.gov/pubmed/34725508 http://dx.doi.org/10.1038/s41551-021-00804-y |
_version_ | 1784697695868289024 |
---|---|
author | Basu, Ishita Yousefi, Ali Crocker, Britni Zelmann, Rina Paulk, Angelique C Peled, Noam Ellard, Kristen K Weisholtz, Daniel S Cosgrove, G. Rees Deckersbach, Thilo Eden, Uri T Eskandar, Emad N Dougherty, Darin D Cash, Sydney S Widge, Alik S |
author_facet | Basu, Ishita Yousefi, Ali Crocker, Britni Zelmann, Rina Paulk, Angelique C Peled, Noam Ellard, Kristen K Weisholtz, Daniel S Cosgrove, G. Rees Deckersbach, Thilo Eden, Uri T Eskandar, Emad N Dougherty, Darin D Cash, Sydney S Widge, Alik S |
author_sort | Basu, Ishita |
collection | PubMed |
description | Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants’ cognitive control during a conflict task. We also show that closed-loop stimulation upon the detection of lapses in cognitive control produced larger behavioural changes than open-loop stimulation, and that task performance for single trials can be directly decoded from the activity of a small number of electrodes, via neural features that are compatible with existing closed-loop brain implants. Closed-loop enhancement of cognitive control might remediate underlying cognitive deficits and aid the treatment of severe mental disorders. |
format | Online Article Text |
id | pubmed-9056584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-90565842023-04-29 Closed-loop enhancement and neural decoding of cognitive control in humans Basu, Ishita Yousefi, Ali Crocker, Britni Zelmann, Rina Paulk, Angelique C Peled, Noam Ellard, Kristen K Weisholtz, Daniel S Cosgrove, G. Rees Deckersbach, Thilo Eden, Uri T Eskandar, Emad N Dougherty, Darin D Cash, Sydney S Widge, Alik S Nat Biomed Eng Article Deficits in cognitive control — that is, in the ability to withhold a default prepotent response in favour of a more adaptive choice — are common in depression, anxiety, addiction and in other mental disorders. Here, we report proof-of-concept evidence that, in participants undergoing intracranial epilepsy monitoring, closed-loop direct stimulation of the internal capsule or striatum, especially the dorsal sites, enhances the participants’ cognitive control during a conflict task. We also show that closed-loop stimulation upon the detection of lapses in cognitive control produced larger behavioural changes than open-loop stimulation, and that task performance for single trials can be directly decoded from the activity of a small number of electrodes, via neural features that are compatible with existing closed-loop brain implants. Closed-loop enhancement of cognitive control might remediate underlying cognitive deficits and aid the treatment of severe mental disorders. 2023-04 2021-11-01 /pmc/articles/PMC9056584/ /pubmed/34725508 http://dx.doi.org/10.1038/s41551-021-00804-y Text en Reprints and permissions information is available at www.nature.com/reprints (http://www.nature.com/reprints) . Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
spellingShingle | Article Basu, Ishita Yousefi, Ali Crocker, Britni Zelmann, Rina Paulk, Angelique C Peled, Noam Ellard, Kristen K Weisholtz, Daniel S Cosgrove, G. Rees Deckersbach, Thilo Eden, Uri T Eskandar, Emad N Dougherty, Darin D Cash, Sydney S Widge, Alik S Closed-loop enhancement and neural decoding of cognitive control in humans |
title | Closed-loop enhancement and neural decoding of cognitive control in humans |
title_full | Closed-loop enhancement and neural decoding of cognitive control in humans |
title_fullStr | Closed-loop enhancement and neural decoding of cognitive control in humans |
title_full_unstemmed | Closed-loop enhancement and neural decoding of cognitive control in humans |
title_short | Closed-loop enhancement and neural decoding of cognitive control in humans |
title_sort | closed-loop enhancement and neural decoding of cognitive control in humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056584/ https://www.ncbi.nlm.nih.gov/pubmed/34725508 http://dx.doi.org/10.1038/s41551-021-00804-y |
work_keys_str_mv | AT basuishita closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT yousefiali closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT crockerbritni closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT zelmannrina closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT paulkangeliquec closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT pelednoam closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT ellardkristenk closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT weisholtzdaniels closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT cosgrovegrees closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT deckersbachthilo closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT edenurit closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT eskandaremadn closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT doughertydarind closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT cashsydneys closedloopenhancementandneuraldecodingofcognitivecontrolinhumans AT widgealiks closedloopenhancementandneuraldecodingofcognitivecontrolinhumans |