Cargando…

Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift

Near-infrared (NIR) fluorescent dyes have attracted increasing attention as fluorescent probes in biomedical applications due to their low biological autofluorescence as well as high tissue penetration depth. However, their being hydrophobic in nature limits their clinical use as they are prone to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Joothamongkon, Jaruwan, Asawapirom, Udom, Thiramanas, Raweewan, Jangpatarapongsa, Kulachart, Polpanich, Duangporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056670/
https://www.ncbi.nlm.nih.gov/pubmed/35515050
http://dx.doi.org/10.1039/d0ra05809b
_version_ 1784697715694764032
author Joothamongkon, Jaruwan
Asawapirom, Udom
Thiramanas, Raweewan
Jangpatarapongsa, Kulachart
Polpanich, Duangporn
author_facet Joothamongkon, Jaruwan
Asawapirom, Udom
Thiramanas, Raweewan
Jangpatarapongsa, Kulachart
Polpanich, Duangporn
author_sort Joothamongkon, Jaruwan
collection PubMed
description Near-infrared (NIR) fluorescent dyes have attracted increasing attention as fluorescent probes in biomedical applications due to their low biological autofluorescence as well as high tissue penetration depth. However, their being hydrophobic in nature limits their clinical use as they are prone to aggregate in the physiological environment. Herein, we have designed and synthesized a novel polymeric NIR fluorescent dye and then encapsulated it into a poly(ε-caprolactone) (PCL) matrix by way of an emulsion–diffusion technique. The effect of the structure of the surfactant on the nanoparticle properties is investigated. Results show that polymeric surfactant, Kolliphor® P188, allows the formation of a high fluorescence intensity of the nanoparticles with the highest level homogeneity and stability. The synthesized nanoparticles show significant advantages in terms of a remarkable large stokes shift (276 nm) in the aqueous solution and excellent biocompatibility. The fabrication process is not limited to encapsulation of polymeric fluorescent dye. The synthesized NIR polymeric nanoparticles would be potentially applicable for biomedical applications.
format Online
Article
Text
id pubmed-9056670
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-90566702022-05-04 Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift Joothamongkon, Jaruwan Asawapirom, Udom Thiramanas, Raweewan Jangpatarapongsa, Kulachart Polpanich, Duangporn RSC Adv Chemistry Near-infrared (NIR) fluorescent dyes have attracted increasing attention as fluorescent probes in biomedical applications due to their low biological autofluorescence as well as high tissue penetration depth. However, their being hydrophobic in nature limits their clinical use as they are prone to aggregate in the physiological environment. Herein, we have designed and synthesized a novel polymeric NIR fluorescent dye and then encapsulated it into a poly(ε-caprolactone) (PCL) matrix by way of an emulsion–diffusion technique. The effect of the structure of the surfactant on the nanoparticle properties is investigated. Results show that polymeric surfactant, Kolliphor® P188, allows the formation of a high fluorescence intensity of the nanoparticles with the highest level homogeneity and stability. The synthesized nanoparticles show significant advantages in terms of a remarkable large stokes shift (276 nm) in the aqueous solution and excellent biocompatibility. The fabrication process is not limited to encapsulation of polymeric fluorescent dye. The synthesized NIR polymeric nanoparticles would be potentially applicable for biomedical applications. The Royal Society of Chemistry 2020-09-09 /pmc/articles/PMC9056670/ /pubmed/35515050 http://dx.doi.org/10.1039/d0ra05809b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Joothamongkon, Jaruwan
Asawapirom, Udom
Thiramanas, Raweewan
Jangpatarapongsa, Kulachart
Polpanich, Duangporn
Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title_full Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title_fullStr Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title_full_unstemmed Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title_short Near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large Stokes shift
title_sort near-infrared polyfluorene encapsulated in poly(ε-caprolactone) nanoparticles with remarkable large stokes shift
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056670/
https://www.ncbi.nlm.nih.gov/pubmed/35515050
http://dx.doi.org/10.1039/d0ra05809b
work_keys_str_mv AT joothamongkonjaruwan nearinfraredpolyfluoreneencapsulatedinpolyecaprolactonenanoparticleswithremarkablelargestokesshift
AT asawapiromudom nearinfraredpolyfluoreneencapsulatedinpolyecaprolactonenanoparticleswithremarkablelargestokesshift
AT thiramanasraweewan nearinfraredpolyfluoreneencapsulatedinpolyecaprolactonenanoparticleswithremarkablelargestokesshift
AT jangpatarapongsakulachart nearinfraredpolyfluoreneencapsulatedinpolyecaprolactonenanoparticleswithremarkablelargestokesshift
AT polpanichduangporn nearinfraredpolyfluoreneencapsulatedinpolyecaprolactonenanoparticleswithremarkablelargestokesshift