Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature

An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room tempera...

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Detalles Bibliográficos
Autores principales: Kim, Hanbi, Kim, Hyun Tae, Lee, Ji Hye, Hwang, Hyonseok, An, Duk Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056805/
https://www.ncbi.nlm.nih.gov/pubmed/35514425
http://dx.doi.org/10.1039/d0ra06023b
Descripción
Sumario:An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room temperature. In addition, DFT calculations for a plausible reaction pathway are reported.

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