Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature

An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room tempera...

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Detalles Bibliográficos
Autores principales: Kim, Hanbi, Kim, Hyun Tae, Lee, Ji Hye, Hwang, Hyonseok, An, Duk Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056805/
https://www.ncbi.nlm.nih.gov/pubmed/35514425
http://dx.doi.org/10.1039/d0ra06023b
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author Kim, Hanbi
Kim, Hyun Tae
Lee, Ji Hye
Hwang, Hyonseok
An, Duk Keun
author_facet Kim, Hanbi
Kim, Hyun Tae
Lee, Ji Hye
Hwang, Hyonseok
An, Duk Keun
author_sort Kim, Hanbi
collection PubMed
description An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room temperature. In addition, DFT calculations for a plausible reaction pathway are reported.
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spelling pubmed-90568052022-05-04 Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature Kim, Hanbi Kim, Hyun Tae Lee, Ji Hye Hwang, Hyonseok An, Duk Keun RSC Adv Chemistry An efficient protocol for the hydroboration of imines is reported. Lithium halide salts are effective catalysts to convert aldimines and ketimines to their corresponding amines. Here, we report excellent isolated yield of secondary amines (>95%) using 3 mol% lithium bromide in THF at room temperature. In addition, DFT calculations for a plausible reaction pathway are reported. The Royal Society of Chemistry 2020-09-17 /pmc/articles/PMC9056805/ /pubmed/35514425 http://dx.doi.org/10.1039/d0ra06023b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kim, Hanbi
Kim, Hyun Tae
Lee, Ji Hye
Hwang, Hyonseok
An, Duk Keun
Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title_full Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title_fullStr Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title_full_unstemmed Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title_short Lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
title_sort lithium bromide: an inexpensive and efficient catalyst for imine hydroboration with pinacolborane at room temperature
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056805/
https://www.ncbi.nlm.nih.gov/pubmed/35514425
http://dx.doi.org/10.1039/d0ra06023b
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AT kimhyuntae lithiumbromideaninexpensiveandefficientcatalystforiminehydroborationwithpinacolboraneatroomtemperature
AT leejihye lithiumbromideaninexpensiveandefficientcatalystforiminehydroborationwithpinacolboraneatroomtemperature
AT hwanghyonseok lithiumbromideaninexpensiveandefficientcatalystforiminehydroborationwithpinacolboraneatroomtemperature
AT andukkeun lithiumbromideaninexpensiveandefficientcatalystforiminehydroborationwithpinacolboraneatroomtemperature

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