P-stereocontrolled synthesis of oligo(nucleoside N3′→O5′ phosphoramidothioate)s – opportunities and limitations

3′-N-(2-Thio-1,3,2-oxathiaphospholane) derivatives of 5′-O-DMT-3′-amino-2′,3′-dideoxy-ribonucleosides ((N)OTP-N), that bear a 4,4-unsubstituted, 4,4-dimethyl, or 4,4-pentamethylene substituted oxathiaphospholane ring, were synthesized. Within these three series, (N)OTP-N differed by canonical nucleo...

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Detalles Bibliográficos
Autores principales: Radzikowska, Ewa, Kaczmarek, Renata, Korczyński, Dariusz, Krakowiak, Agnieszka, Mikołajczyk, Barbara, Baraniak, Janina, Guga, Piotr, Wheeler, Kraig A., Pawlak, Tomasz, Nawrot, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056831/
https://www.ncbi.nlm.nih.gov/pubmed/35515667
http://dx.doi.org/10.1039/d0ra04987e

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