Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism

Brain-derived neurotrophic factor (BDNF), which is expressed at high levels in the limbic system, has been shown to regulate learning, memory and cognition. Thyroid hormone is crucial for brain development. Hypothyroidism is a clinical condition in which thyroid hormones are reduced and it affects t...

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Autores principales: Madhusudhan, U, M, Kalpana, Singaravelu, Vidya, Ganji, Vidya, John, Nitin, Gaur, Archana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056880/
https://www.ncbi.nlm.nih.gov/pubmed/35506116
http://dx.doi.org/10.7759/cureus.23722
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author Madhusudhan, U
M, Kalpana
Singaravelu, Vidya
Ganji, Vidya
John, Nitin
Gaur, Archana
author_facet Madhusudhan, U
M, Kalpana
Singaravelu, Vidya
Ganji, Vidya
John, Nitin
Gaur, Archana
author_sort Madhusudhan, U
collection PubMed
description Brain-derived neurotrophic factor (BDNF), which is expressed at high levels in the limbic system, has been shown to regulate learning, memory and cognition. Thyroid hormone is crucial for brain development. Hypothyroidism is a clinical condition in which thyroid hormones are reduced and it affects the growth and development of the brain in neonates and progresses to cognitive impairment in adults. The exact mechanism of how reduced thyroid hormones impairs cognition and memory is not well understood. This review explores the possible role of BDNF-mediated cognitive impairment in hypothyroid patients.
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spelling pubmed-90568802022-05-02 Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism Madhusudhan, U M, Kalpana Singaravelu, Vidya Ganji, Vidya John, Nitin Gaur, Archana Cureus Endocrinology/Diabetes/Metabolism Brain-derived neurotrophic factor (BDNF), which is expressed at high levels in the limbic system, has been shown to regulate learning, memory and cognition. Thyroid hormone is crucial for brain development. Hypothyroidism is a clinical condition in which thyroid hormones are reduced and it affects the growth and development of the brain in neonates and progresses to cognitive impairment in adults. The exact mechanism of how reduced thyroid hormones impairs cognition and memory is not well understood. This review explores the possible role of BDNF-mediated cognitive impairment in hypothyroid patients. Cureus 2022-04-01 /pmc/articles/PMC9056880/ /pubmed/35506116 http://dx.doi.org/10.7759/cureus.23722 Text en Copyright © 2022, Madhusudhan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Madhusudhan, U
M, Kalpana
Singaravelu, Vidya
Ganji, Vidya
John, Nitin
Gaur, Archana
Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title_full Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title_fullStr Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title_full_unstemmed Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title_short Brain-Derived Neurotrophic Factor-Mediated Cognitive Impairment in Hypothyroidism
title_sort brain-derived neurotrophic factor-mediated cognitive impairment in hypothyroidism
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056880/
https://www.ncbi.nlm.nih.gov/pubmed/35506116
http://dx.doi.org/10.7759/cureus.23722
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