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Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior

Pyrazinamide (PZA) is one of the essential anti-mycobacterium drugs, active against non-replicating Mycobacterium tuberculosis (MTB) isolates. PZA is converted into its active state, called pyrazinoic acid (POA), by action of pncA encoding pyrazinamidase (PZase). In the majority of PZA-resistance is...

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Detalles Bibliográficos
Autores principales:	Ali, Arif, Khan, Muhammad Tahir, Khan, Abbas, Ali, Sajid, Chinnasamy, Sathishkumar, Akhtar, Khalid, Shafiq, Athar, Wei, Dong-Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056903/ https://www.ncbi.nlm.nih.gov/pubmed/35515677 http://dx.doi.org/10.1039/d0ra06072k

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