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Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal
PEC is a new generation of phosphamide ester anti-hepatitis B virus drug. It is a prodrug of tenofovir and can be rapidly metabolized to tenofovir. However, its poor solubility in water (0.219 mg mL(−1) at 25 °C) has limited its oral bioavailability. In this study, we aimed to improve the solubility...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056957/ https://www.ncbi.nlm.nih.gov/pubmed/35517067 http://dx.doi.org/10.1039/d0ra06608g |