A biocompatible PAA-Cu-MOP hydrogel for wound healing

Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial...

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Detalles Bibliográficos
Autores principales: Chen, Linlin, Qin, Yu, Cheng, Jing, Cheng, Yi, Lu, Zhixiang, Liu, Xiaolan, Yang, Shaoxiong, Lu, Shuhan, Zheng, Liyan, Cao, Qiue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056958/
https://www.ncbi.nlm.nih.gov/pubmed/35517077
http://dx.doi.org/10.1039/c9ra10031h
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author Chen, Linlin
Qin, Yu
Cheng, Jing
Cheng, Yi
Lu, Zhixiang
Liu, Xiaolan
Yang, Shaoxiong
Lu, Shuhan
Zheng, Liyan
Cao, Qiue
author_facet Chen, Linlin
Qin, Yu
Cheng, Jing
Cheng, Yi
Lu, Zhixiang
Liu, Xiaolan
Yang, Shaoxiong
Lu, Shuhan
Zheng, Liyan
Cao, Qiue
author_sort Chen, Linlin
collection PubMed
description Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors.
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spelling pubmed-90569582022-05-04 A biocompatible PAA-Cu-MOP hydrogel for wound healing Chen, Linlin Qin, Yu Cheng, Jing Cheng, Yi Lu, Zhixiang Liu, Xiaolan Yang, Shaoxiong Lu, Shuhan Zheng, Liyan Cao, Qiue RSC Adv Chemistry Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors. The Royal Society of Chemistry 2020-10-01 /pmc/articles/PMC9056958/ /pubmed/35517077 http://dx.doi.org/10.1039/c9ra10031h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Chen, Linlin
Qin, Yu
Cheng, Jing
Cheng, Yi
Lu, Zhixiang
Liu, Xiaolan
Yang, Shaoxiong
Lu, Shuhan
Zheng, Liyan
Cao, Qiue
A biocompatible PAA-Cu-MOP hydrogel for wound healing
title A biocompatible PAA-Cu-MOP hydrogel for wound healing
title_full A biocompatible PAA-Cu-MOP hydrogel for wound healing
title_fullStr A biocompatible PAA-Cu-MOP hydrogel for wound healing
title_full_unstemmed A biocompatible PAA-Cu-MOP hydrogel for wound healing
title_short A biocompatible PAA-Cu-MOP hydrogel for wound healing
title_sort biocompatible paa-cu-mop hydrogel for wound healing
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9056958/
https://www.ncbi.nlm.nih.gov/pubmed/35517077
http://dx.doi.org/10.1039/c9ra10031h
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