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Quantitative analysis of hydrogen and chalcogen bonds in two pyrimidine-5-carbonitrile derivatives, potential DHFR inhibitors: an integrated crystallographic and theoretical study

Two potential bioactive pyrimidine-5-carbonitrile derivatives have been synthesized and characterized by spectroscopic techniques ((1)H and (13)C-NMR) and the three dimensional structures were elucidated by single crystal X-ray diffraction at low temperature (160 K). In both structures, the molecula...

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Detalles Bibliográficos
Autores principales:	Al-Wahaibi, Lamya H., Chakraborty, Kushumita, Al-Shaalan, Nora H., Syed Majeed, Mohamed Yehya Annavi, Blacque, Olivier, Al-Mutairi, Aamal A., El-Emam, Ali A., Percino, M. Judith, Thamotharan, Subbiah
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057057/ https://www.ncbi.nlm.nih.gov/pubmed/35517953 http://dx.doi.org/10.1039/d0ra07215j

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