A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells

Peroxynitrite (ONOO(−)) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. Wit...

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Detalles Bibliográficos
Autores principales: Liu, Xiling, Gu, Fangyuan, Zhou, Xinyi, Zhou, Wei, Zhang, Shuping, Cui, Lei, Guo, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057252/
https://www.ncbi.nlm.nih.gov/pubmed/35517529
http://dx.doi.org/10.1039/d0ra06564a
Descripción
Sumario:Peroxynitrite (ONOO(−)) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO(−) distribution in HepG2 cells and live C. elegans in real time. Therefore, the probe can be a promising tool for imaging in vivo.

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