A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells

Peroxynitrite (ONOO(−)) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. Wit...

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Detalles Bibliográficos
Autores principales: Liu, Xiling, Gu, Fangyuan, Zhou, Xinyi, Zhou, Wei, Zhang, Shuping, Cui, Lei, Guo, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057252/
https://www.ncbi.nlm.nih.gov/pubmed/35517529
http://dx.doi.org/10.1039/d0ra06564a
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author Liu, Xiling
Gu, Fangyuan
Zhou, Xinyi
Zhou, Wei
Zhang, Shuping
Cui, Lei
Guo, Ting
author_facet Liu, Xiling
Gu, Fangyuan
Zhou, Xinyi
Zhou, Wei
Zhang, Shuping
Cui, Lei
Guo, Ting
author_sort Liu, Xiling
collection PubMed
description Peroxynitrite (ONOO(−)) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO(−) distribution in HepG2 cells and live C. elegans in real time. Therefore, the probe can be a promising tool for imaging in vivo.
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spelling pubmed-90572522022-05-04 A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells Liu, Xiling Gu, Fangyuan Zhou, Xinyi Zhou, Wei Zhang, Shuping Cui, Lei Guo, Ting RSC Adv Chemistry Peroxynitrite (ONOO(−)) is a potent biological oxidant that plays a significant role in diverse physiological and pathological processes. A novel fluorescent probe HCA-OH was developed for specific and sensitive detection of peroxynitrite, and displayed a significant fluorescence turn-on signal. With low cytotoxicity and good photostability, the probe HCA-OH could be applied in imaging ONOO(−) distribution in HepG2 cells and live C. elegans in real time. Therefore, the probe can be a promising tool for imaging in vivo. The Royal Society of Chemistry 2020-10-16 /pmc/articles/PMC9057252/ /pubmed/35517529 http://dx.doi.org/10.1039/d0ra06564a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Xiling
Gu, Fangyuan
Zhou, Xinyi
Zhou, Wei
Zhang, Shuping
Cui, Lei
Guo, Ting
A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title_full A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title_fullStr A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title_full_unstemmed A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title_short A naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
title_sort naphthalimide-based turn-on fluorescence probe for peroxynitrite detection and imaging in living cells
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057252/
https://www.ncbi.nlm.nih.gov/pubmed/35517529
http://dx.doi.org/10.1039/d0ra06564a
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